Description
Clopidogrel-Zentiva Coated Tablets 75 mg. №30
Ingredients
Active ingredient: Clopidogrel bisulfate. Other ingredients: mannitol, microcrystalline cellulose, hydrogenated castor oil, hydroxypropyl cellulose, colloidal anhydrous silica, croscarmellose sodium, and magnesium stearate.
Mechanism of Action
Clopidogrel-Zentiva acts by irreversibly inhibiting platelet aggregation through the blockade of the P2Y12 ADP receptor, thus impeding thrombus formation and reducing the risk of atherothrombotic events.
Pharmacological Properties
The pharmacological properties of Clopidogrel-Zentiva involve its antiplatelet action, which plays a crucial role in preventing cardiovascular events by inhibiting platelet activation and aggregation.
Indications for Use
Indicated for: Prevention of atherothrombotic events in patients with acute coronary syndrome, recent myocardial infarction, ischemic stroke, or established peripheral arterial disease.
Contraindications
Contraindications: Avoid use in individuals hypersensitive to clopidogrel or any component of the formulation, those with active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage), or severe hepatic impairment.
Side Effects
Common side effects may include gastrointestinal disturbances, bruising, or rash. Severe allergic reactions are rare but possible. Consult a healthcare provider if any adverse effects occur.
Usage Instructions
Dosage: The typical dose is one tablet daily, orally, with or without food, or as prescribed by a healthcare professional. Swallow the tablet whole with water; do not crush or chew.
Benefits Compared to Analogues
Clopidogrel-Zentiva has demonstrated efficacy in reducing cardiovascular risk based on clinical trials. Studies have shown a significant decrease in the combined risk of cardiovascular death, myocardial infarction, or stroke compared to placebo.
Suitable Patient Groups
Clopidogrel-Zentiva can be used in various patient populations, including adults, the elderly, and specific pediatric cases under medical supervision. Dosage adjustments may be necessary based on individual health conditions.
Storage and Shelf Life
Store Clopidogrel-Zentiva in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use the product after the specified shelf life has passed.
Packaging Description
The product is available in blister packs containing 30 coated tablets of 75 mg strength. Each tablet is labeled with essential information, including the name, dosage, and expiration date.
Scientific Evidence
Clopidogrel-Zentiva has been extensively studied in clinical trials, demonstrating its effectiveness in reducing the risk of cardiovascular events. Notably, research published in the New England Journal of Medicine highlighted a significant reduction in the combined risk of cardiovascular death, myocardial infarction, or stroke with clopidogrel therapy compared to placebo.
Additional Information
Caution is advised when using Clopidogrel-Zentiva in patients at risk of bleeding, such as those with a history of peptic ulcer or intracranial hemorrhage. Regular monitoring of platelet function is recommended during treatment to adjust therapy as needed.
