Description

Clopidogrel-Zentiva Coated Tablets 75 mg. №30

Ingredients

Active ingredient: Clopidogrel bisulfate. Other ingredients: mannitol, microcrystalline cellulose, hydrogenated castor oil, hydroxypropyl cellulose, colloidal anhydrous silica, croscarmellose sodium, and magnesium stearate.

Dosage

Recommended dosage: The usual dose is one tablet daily, taken orally with or without food, or as directed by a healthcare professional.

Indications

Indicated for: Prevention of atherothrombotic events in patients suffering from acute coronary syndrome, recent myocardial infarction, ischemic stroke, or established peripheral arterial disease.

Contraindications

Do not use if: Hypersensitive to clopidogrel or any component of the formulation, active pathological bleeding (such as peptic ulcer or intracranial hemorrhage), or severe hepatic impairment.

Directions

Administration: Swallow the tablet whole with water. Do not crush or chew the tablet. Follow the prescribed dosage regimen strictly.

Scientific Evidence

Clopidogrel-Zentiva has been extensively studied in various clinical trials, demonstrating its efficacy in reducing the risk of cardiovascular events. Research published in the New England Journal of Medicine showed a significant reduction in the combined risk of cardiovascular death, myocardial infarction, or stroke with clopidogrel therapy compared to placebo.

Additional Information

It is important to note that Clopidogrel-Zentiva should be used with caution in patients at risk of bleeding, such as those with a history of peptic ulcer or intracranial hemorrhage. Regular monitoring is recommended during treatment to assess platelet function and adjust therapy if necessary.

Furthermore, the pharmacological action of clopidogrel involves irreversibly inhibiting platelet aggregation by blocking the P2Y12 ADP receptor, thereby preventing thrombus formation. This mechanism of action makes it a vital component in the management of atherothrombotic conditions.