Description

Clopidogrel-Zentiva Coated Tablets 75 mg. №90

Ingredients

Active ingredient: Clopidogrel bisulfate. Inactive ingredients: microcrystalline cellulose, hydrogenated castor oil, hydroxypropyl cellulose, hypromellose, mannitol, titanium dioxide, talc, and more.

Dosage

Recommended dosage: The usual dose is one tablet daily, with or without food, or as directed by a healthcare professional.

Indications

Indicated for: Prevention of atherothrombotic events in patients suffering from acute coronary syndrome, recent myocardial infarction, ischemic stroke, or established peripheral arterial disease.

Contraindications

Do not use if: Hypersensitive to clopidogrel or any component of the formulation, active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

Directions

Administration: Swallow the tablet whole with water. Do not crush or chew the tablet. Consult a healthcare provider for specific instructions.

Scientific Evidence

Clopidogrel-Zentiva has been extensively studied in various clinical trials to establish its efficacy in reducing cardiovascular events. Research published in the New England Journal of Medicine demonstrated that clopidogrel, in combination with aspirin, significantly reduced the risk of major cardiovascular events in patients with acute coronary syndrome.

Additional Information

Clopidogrel-Zentiva works by irreversibly inhibiting the P2Y12 adenosine diphosphate receptor on platelets, thereby preventing platelet aggregation and reducing the risk of thrombotic events. This antiplatelet effect plays a crucial role in the management of cardiovascular diseases.

Compared to other antiplatelet agents, clopidogrel has shown similar efficacy in preventing cardiovascular events with a lower risk of gastrointestinal bleeding, making it a preferred choice in many clinical scenarios.