Description
Clopixol (Zuclopenthixol) Coated Tablets 10 mg. №100
Ingredients
Active ingredient: Zuclopenthixol. Other ingredients: lactose, maize starch, povidone, magnesium stearate, talc, and hypromellose.
Mechanism of Action
Zuclopenthixol, the active ingredient in Clopixol, acts as a dopamine antagonist, exerting its antipsychotic effects by blocking dopamine receptors in the brain. This action helps regulate neurotransmitter imbalances associated with psychotic disorders.
Pharmacological Properties
Zuclopenthixol is a potent dopamine antagonist that modulates dopaminergic activity in the brain, thereby alleviating symptoms of schizophrenia and other psychotic disorders. It exhibits high affinity for dopamine receptors, leading to effective management of positive and negative symptoms.
Indications for Use
Indicated for: Treatment of schizophrenia and other psychotic disorders where long-term medication is indicated.
Contraindications
Do not use Clopixol if: allergic to zuclopenthixol, have CNS depression, comatose states, severe hypotension, or blood dyscrasias.
Side Effects
Common side effects of Clopixol may include drowsiness, dizziness, dry mouth, and constipation. It is important to consult a healthcare provider if any severe reactions occur.
Usage Instructions
Recommended dosage: The usual starting dose is 10-20 mg daily in divided doses. Dosage may vary based on individual response and condition severity. Swallow the tablets whole with water. Can be taken with or without food. Follow the dosage instructions provided by your healthcare provider.
Benefits Compared to Analogues
Clopixol offers a favorable efficacy and safety profile compared to other antipsychotic medications. Its dopamine-blocking properties provide effective symptom relief with a lower risk of certain adverse effects commonly associated with similar drugs.
Suitable Patient Groups
Clopixol is suitable for adult patients with schizophrenia and other chronic psychotic disorders. It is not recommended for children, elderly individuals with cognitive impairments, or individuals with a history of sensitivity to antipsychotic medications without proper medical supervision.
Storage and Shelf Life
- Storage: Store at room temperature away from moisture and heat.
- Shelf Life: Check the expiration date on the packaging. Do not use after the stated expiry date.
Packaging Description
Clopixol is available in blister packs containing 100 coated tablets of 10 mg each. The packaging is designed to protect the tablets from environmental factors and maintain their stability until the expiration date.
Clinical Evidence and Proven Effectiveness
Pharmacological Effects: Zuclopenthixol’s mechanism of action as a dopamine antagonist has been extensively studied and validated in clinical settings. Its ability to modulate dopaminergic neurotransmission contributes to the effective management of psychotic symptoms.
Clinical Trials: Clinical studies have demonstrated the efficacy of zuclopenthixol in managing symptoms of schizophrenia and other psychotic disorders. A randomized controlled trial published in the Journal of Clinical Psychopharmacology showed significant improvements in positive and negative symptoms with zuclopenthixol treatment compared to placebo.
