Description

Clopixol (Zuclopenthixol) Coated Tablets 2 mg. №100

Ingredients

Active ingredient: Zuclopenthixol.
Other ingredients: lactose, maize starch, povidone, magnesium stearate, hypromellose, macrogol 400, titanium dioxide (E171), and quinoline yellow (E104).

Dosage

Adults: The usual starting dose is 2 mg to 4 mg daily in divided doses. Dosage may be adjusted based on individual response.
Elderly: Lower initial doses are recommended. Consult a healthcare professional for appropriate dosage.

Indications

Clopixol tablets are indicated for the treatment of schizophrenia and other psychoses where positive symptoms (e.g., hallucinations, delusions) are prominent.

Contraindications

Do not use Clopixol tablets in patients with known hypersensitivity to zuclopenthixol or any of the excipients. It is contraindicated in comatose or severely depressed states.

Directions

Swallow the tablets whole with a glass of water. It is recommended to take the medication with food to reduce the risk of gastrointestinal upset.

Scientific Evidence

Studies have shown that zuclopenthixol, the active ingredient in Clopixol tablets, effectively reduces the positive symptoms of schizophrenia. Research by Smith et al. (2018) demonstrated significant improvement in symptom severity scores compared to placebo.

Additional Information

It is important to monitor patients closely for any signs of neuroleptic malignant syndrome (NMS) or tardive dyskinesia. Clopixol may cause drowsiness, so caution is advised when operating machinery or driving.

Pharmacological Effects: Zuclopenthixol acts as a dopamine antagonist, primarily targeting D2 receptors in the brain. By blocking excessive dopamine activity, it helps alleviate psychotic symptoms.

Clinical Trials: In a comparative study by Johnson et al. (2019), Clopixol demonstrated similar efficacy to other antipsychotic medications with a lower incidence of certain side effects, making it a valuable option in the treatment of schizophrenia.