Description

Closart (losartan) Coated Tablets 100 mg. №30

Ingredients:

Each tablet contains 100 mg of losartan potassium as the active ingredient. Other ingredients include lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, and more.

Dosage:

The usual starting dose is 50 mg once daily. The dosage may be increased to 100 mg once daily based on blood pressure response.

Indications:

Closart tablets are indicated for the treatment of hypertension and to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Contraindications:

Do not use Closart if you are pregnant, have severe liver impairment, or are allergic to losartan. It is also contraindicated in patients with bilateral renal artery stenosis.

Directions:

Take Closart tablets exactly as prescribed by your healthcare provider. It can be taken with or without food.

Scientific Evidence:

Losartan, the active ingredient in Closart tablets, is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to constrict. Several studies have demonstrated the efficacy of losartan in lowering blood pressure and reducing the risk of cardiovascular events.

Additional Information:

It is important to regularly monitor blood pressure while taking Closart tablets. Some common side effects may include dizziness, fatigue, and hyperkalemia. Consult your healthcare provider if you experience any adverse reactions.

Pharmacological Effects: Losartan selectively blocks the angiotensin II receptor, leading to vasodilation and decreased secretion of aldosterone. This results in reduced blood pressure and improved cardiac function.

Clinical Trials: Clinical trials have shown that losartan is effective in reducing blood pressure and has a good safety profile. A study published in the Journal of Hypertension demonstrated that losartan was well-tolerated and effective in lowering blood pressure in patients with essential hypertension.