Description

Clotrex (clotrimazole, gentamicin sulfate) Ointment 25 g Tube

Ingredients

Active ingredients: Clotrimazole, Gentamicin Sulfate

Dosage

Dosage: Apply a thin layer of the ointment to the affected area 2-3 times a day.

Indications

Indicated for: Fungal skin infections and bacterial skin infections.

Contraindications

Do not use if: Allergic to any of the ingredients. Consult a healthcare professional before use.

Directions

Directions: Clean and dry the affected area before applying the ointment. Wash hands after application.

Scientific Evidence

Clotrex ointment has shown efficacy in treating various fungal and bacterial skin infections. Studies have demonstrated the effectiveness of clotrimazole in combating fungal growth, while gentamicin sulfate provides broad-spectrum antibacterial action.

Additional Information

It is important to complete the full course of treatment as prescribed by a healthcare provider to ensure the infection is fully eradicated. Avoid contact with eyes and mucous membranes. If irritation occurs, discontinue use and consult a doctor.

Pharmacological Effects

Clotrimazole works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, leading to cell death. Gentamicin sulfate disrupts bacterial protein synthesis, effectively killing a wide range of bacteria. The combination of these two agents in Clotrex ointment provides a dual-action approach against mixed infections.

Clinical Trials and Comparative Effectiveness

Several clinical trials have shown the superior efficacy of Clotrex ointment compared to individual clotrimazole or gentamicin formulations in treating mixed fungal and bacterial skin infections. The synergistic effect of the two components results in faster resolution of symptoms and lower rates of recurrence.