Description

Co-Diroton tablets 10 mg/12.5 mg. №30

Ingredients

Co-Diroton tablets contain 10 mg of lisinopril and 12.5 mg of hydrochlorothiazide as active ingredients.

Dosage

The recommended dosage is one tablet once daily. It is important to follow the instructions provided by your healthcare provider.

Indications

Co-Diroton tablets are indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled by monotherapy.

Contraindications

Do not use Co-Diroton tablets if you are allergic to any of the ingredients, have a history of angioedema related to previous treatment with ACE inhibitors, or if you are pregnant.

Directions

Take Co-Diroton tablets exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water, with or without food.

Scientific Evidence

Studies have shown that the combination of lisinopril and hydrochlorothiazide in Co-Diroton tablets is effective in lowering blood pressure in patients with hypertension. Research published in the Journal of Clinical Hypertension demonstrated that this combination therapy resulted in a significant reduction in both systolic and diastolic blood pressure levels compared to placebo.

Additional Information

It is important to monitor your blood pressure regularly while taking Co-Diroton tablets. Inform your healthcare provider about any side effects or concerns. Avoid alcohol and limit salt intake while on this medication.

Pharmacological Effects: Lisinopril works by inhibiting the angiotensin-converting enzyme, leading to vasodilation and reduced aldosterone secretion. Hydrochlorothiazide acts on the kidneys to increase the excretion of sodium and water, further lowering blood pressure.

Clinical Trials: A randomized controlled trial published in the American Journal of Medicine compared the efficacy of Co-Diroton tablets with other antihypertensive medications. The study found that the combination of lisinopril and hydrochlorothiazide was well-tolerated and effective in reducing blood pressure levels.