Description

Co-Prenesa (perindopril tert-butylamine, Indapamide) tablets 4 mg/1.25 mg. №30

Ingredients

Active ingredients: Perindopril tert-butylamine 4 mg, Indapamide 1.25 mg.

Dosage

Dosage: The recommended dose is one tablet daily, preferably taken in the morning before a meal.

Indications

Indications: Co-Prenesa tablets are indicated for the treatment of hypertension to lower blood pressure.

Contraindications

Contraindications: Do not use Co-Prenesa if you are allergic to any of the ingredients, have a history of angioedema related to previous ACE inhibitor therapy, or if you are pregnant.

Directions

Directions: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

Scientific Evidence

There is strong scientific evidence supporting the efficacy of Co-Prenesa in the management of hypertension. A study published in the Journal of Clinical Hypertension demonstrated that the combination of perindopril and Indapamide led to a significant reduction in blood pressure levels compared to placebo.

Additional Information

It is important to regularly monitor blood pressure levels while taking Co-Prenesa to ensure optimal control. In case of any side effects or concerns, consult a healthcare professional for guidance.

Pharmacological Effects

Perindopril, an ACE inhibitor, works by blocking the enzyme that converts angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Indapamide, a thiazide-like diuretic, promotes diuresis and helps in lowering blood pressure by reducing blood volume.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown that the combination of perindopril and Indapamide is more effective in reducing blood pressure compared to either drug alone. A study in the European Heart Journal found that this combination therapy significantly reduced the risk of cardiovascular events in hypertensive patients.

Overall, Co-Prenesa tablets offer a well-established and effective treatment option for individuals with hypertension, backed by scientific research and clinical evidence.