Description

Co-Prenesa (perindopril tert-butylamine, Indapamide) tablets 8 mg/2.5 mg. №90

Ingredients

Active ingredients: Perindopril tert-butylamine, Indapamide

Dosage

Recommended dosage: One tablet daily, or as directed by a healthcare professional.

Indications

Indicated for: Hypertension and heart failure.

Contraindications

Do not use if: Allergic to any component, history of angioedema related to previous ACE inhibitor therapy.

Directions

Directions for use: Swallow the tablet whole with water, preferably in the morning.

Scientific Evidence

Clinical trials have shown that the combination of perindopril and Indapamide in Co-Prenesa tablets effectively lowers blood pressure and reduces the risk of cardiovascular events in patients with hypertension. The synergistic effect of these two components provides comprehensive cardiovascular protection.

Additional Information

Precautions: Regular monitoring of blood pressure and renal function is recommended during treatment with Co-Prenesa tablets. Avoid in pregnancy and breastfeeding.

Storage: Store in a cool, dry place away from direct sunlight.

Pharmacological Effects

Perindopril, an ACE inhibitor, works by inhibiting the angiotensin-converting enzyme, leading to vasodilation and reduced aldosterone secretion. Indapamide, a thiazide-like diuretic, promotes diuresis and vasodilation by inhibiting sodium reabsorption in the distal convoluted tubule. The combination of these mechanisms results in effective blood pressure control and cardiovascular protection.

Clinical Trials and Comparative Effectiveness

Studies have demonstrated that the combination of perindopril and Indapamide is more effective in reducing blood pressure compared to either drug alone. Additionally, Co-Prenesa has shown superior cardiovascular outcomes compared to other antihypertensive agents. Its unique dual action makes it a valuable option in the management of hypertension and heart failure.