Description

Combogliza XR (saxagliptin, metformin) Coated Tablets 2.5 mg/1000 mg. №28

Ingredients

Active ingredients: Saxagliptin 2.5 mg and Metformin 1000 mg. Inactive ingredients include microcrystalline cellulose, hypromellose, magnesium stearate, and others.

Dosage

Recommended dosage: The usual starting dose is one tablet once daily with meals. Dosage may vary based on individual needs and response to treatment.

Indications

Indicated for: Combogliza XR is prescribed for the management of type 2 diabetes mellitus in adults to improve glycemic control.

Contraindications

Do not use Combogliza XR if:

• You have a history of allergic reactions to saxagliptin or metformin.
• You have severe renal impairment or metabolic acidosis.

Directions

Follow these directions: Take Combogliza XR exactly as prescribed by your healthcare provider. Do not alter the dosage or stop the medication without consulting your doctor.

Scientific Evidence

Pharmacological effects: Saxagliptin works by increasing insulin release and decreasing glucagon levels, while metformin improves insulin sensitivity and reduces hepatic glucose production. This dual mechanism helps in better glycemic control.

Clinical trials: Clinical studies have shown that the combination of saxagliptin and metformin in Combogliza XR leads to significant reductions in HbA1c levels compared to either drug alone. Additionally, it has been demonstrated to be well-tolerated with a low risk of hypoglycemia.

Additional Information

It is essential to monitor renal function regularly while on Combogliza XR therapy, as metformin can cause lactic acidosis in patients with renal impairment. Inform your healthcare provider of any signs of hypoglycemia or other adverse effects.

Always carry a source of sugar with you in case of low blood sugar episodes. Combogliza XR should be stored at room temperature away from moisture and heat.