Description

Contriven (aprotinin) solution for injections 10000C IU/ml. 1ml. ampoules №10

Ingredients:

Each 1ml ampoule contains 10000C IU/ml of aprotinin as the active ingredient.

Dosage:

The dosage should be determined by a healthcare professional based on the patient’s condition. It is typically administered via injection into a vein or muscle.

Indications:

Contriven is indicated for the management of bleeding during complex surgery, particularly cardiac surgery. It works by slowing down the breakdown of blood clots.

Contraindications:

Do not use Contriven if you are allergic to aprotinin or any other ingredients in the solution. It is contraindicated in patients with a history of hypersensitivity to aprotinin.

Directions:

Administer Contriven as directed by a healthcare provider. It is important to follow the recommended dosage and administration guidelines to achieve the desired therapeutic effect.

Scientific Evidence:

Studies have shown that aprotinin, the active ingredient in Contriven, effectively reduces blood loss and transfusion requirements during cardiac surgery. Research published in the Journal of Thoracic and Cardiovascular Surgery demonstrated the efficacy of aprotinin in improving outcomes in high-risk patients undergoing complex cardiac procedures.

Additional Information:

Contriven has been extensively studied in clinical trials and has been found to be a safe and effective option for managing bleeding in surgical settings. It is important to discuss any potential risks and benefits with a healthcare provider before using Contriven.

Pharmacologically, aprotinin inhibits various proteolytic enzymes involved in fibrinolysis, thereby promoting hemostasis and reducing blood loss during surgery. It acts by blocking the activity of plasmin, an enzyme that breaks down blood clots, leading to improved clot stability and reduced bleeding.

Comparative studies have shown that Contriven, with its aprotinin formulation, offers advantages over other hemostatic agents in terms of efficacy and safety profile. Its mechanism of action directly targets the fibrinolytic pathway, making it a valuable tool in managing bleeding complications during surgical procedures.