Description

Contriven (aprotinin) Solution for Injections 10000C IU/ml – 1ml Ampoules Pack of 10

Composition:

Each 1ml ampoule of Contriven contains 10000C IU/ml of aprotinin as the active ingredient.

Mechanism of Action:

Pharmacologically, aprotinin inhibits various proteolytic enzymes involved in fibrinolysis, promoting hemostasis and reducing blood loss during surgery. By blocking the activity of plasmin, an enzyme responsible for breaking down blood clots, Contriven enhances clot stability and decreases bleeding.

Indications:

Contriven is indicated for the management of bleeding during complex surgeries, particularly cardiac procedures. It functions by slowing down the breakdown of blood clots.

Contraindications:

Avoid using Contriven if allergic to aprotinin or any other components in the solution. It is contraindicated in individuals with a history of hypersensitivity to aprotinin.

Side Effects:

Common side effects of Contriven may include allergic reactions, nausea, vomiting, and injection site reactions. Serious side effects such as anaphylaxis or thrombosis may also occur.

Usage Instructions:

Contriven should be administered as directed by a healthcare professional. The dosage is individualized based on the patient’s specific condition and is typically given via intravenous or intramuscular injection.

Benefits Over Analogues:

Comparative studies have demonstrated that Contriven, with its aprotinin formulation, offers superior efficacy and safety compared to other hemostatic agents. Its targeted mechanism of action on the fibrinolytic pathway makes it a valuable tool in managing bleeding complications during surgeries.

Suitable Patient Groups:

Contriven is suitable for adult patients undergoing complex surgical procedures, including the elderly population. It is not recommended for children without proper medical supervision.

Storage and Shelf Life:

Store Contriven as per the instructions on the packaging. Ensure proper storage conditions to maintain its effectiveness. Check the expiry date before use and do not use expired product.

Packaging Description:

Contriven is available in packs containing 10 ampoules, each with a volume of 1ml. The packaging should be intact and undamaged before use.

Clinical Evidence and Effectiveness:

Studies have shown that aprotinin in Contriven effectively reduces blood loss and transfusion requirements during cardiac surgeries. Research in the Journal of Thoracic and Cardiovascular Surgery highlighted its efficacy in improving outcomes for high-risk patients undergoing complex cardiac procedures.