Description

Convulex (valproic acid) solution for injections 100 mg/ml. ampoules 5 ml. №5

Ingredients

Active ingredient: Valproic acid. Inactive ingredients may include propylene glycol, water for injections, and sodium hydroxide.

Dosage

Dosage: The usual starting dose is 10-15 mg/kg/day, divided into 2-3 doses. Dosage may be increased gradually based on patient response.

Indications

Indicated for: Convulsive seizures, bipolar disorder, and migraine prophylaxis.

Contraindications

Contraindications: Hypersensitivity to valproic acid, hepatic disease, and urea cycle disorders.

Directions

Administration: Administer intravenously at a rate not exceeding 20 mg/min.

Scientific Evidence

Scientific evidence: Studies have shown the efficacy of valproic acid in managing various seizure disorders and bipolar disorder. Research by Smith et al. (2018) demonstrated a significant reduction in seizure frequency with valproic acid treatment.

Additional Information

Storage: Store at controlled room temperature between 20-25°C (68-77°F). Protect from light.

Pregnancy: Valproic acid may cause fetal harm when administered to a pregnant woman. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Pharmacological Effects: Valproic acid exerts its anticonvulsant effects by increasing the brain’s levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. It also modulates voltage-gated sodium channels, reducing neuronal excitability.

Clinical Trials: Clinical trials have shown that valproic acid is effective in the treatment of various seizure types, including absence seizures and generalized tonic-clonic seizures. It has also been found to be beneficial in the management of bipolar disorder, reducing manic episodes and stabilizing mood.