Description
Coripren (Enalapril, Lercanidipine) Coated Tablets 20 mg/10 mg. №56
Ingredients
Each tablet contains 20 mg of enalapril and 10 mg of lercanidipine.
Mechanism of Action
Coripren tablets combine enalapril, an angiotensin-converting enzyme inhibitor that leads to vasodilation, with lercanidipine, a calcium channel blocker that relaxes blood vessels. This dual mechanism helps in lowering blood pressure effectively.
Pharmacological Properties
Enalapril inhibits the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Lercanidipine blocks calcium channels in vascular smooth muscle, leading to vasodilation. The combination of these two components in Coripren tablets results in a synergistic antihypertensive effect.
Indications for Use
Coripren tablets are indicated for the treatment of hypertension. They are prescribed to reduce blood pressure levels and decrease the risk of cardiovascular events associated with high blood pressure.
Contraindications
Avoid using Coripren tablets if you have a known allergy to enalapril, lercanidipine, or any other components of the product. These tablets are contraindicated during pregnancy and breastfeeding due to potential risks to the fetus or infant.
Side Effects
Common side effects of Coripren may include dizziness, headache, and cough. If you experience severe or persistent side effects, seek medical attention promptly. Adverse reactions should be reported to your healthcare provider.
Usage Instructions
The recommended dose is one tablet per day, taken orally with water. Follow the dosage instructions provided by your healthcare professional carefully. Do not exceed the prescribed amount of Coripren tablets.
Benefits Compared to Analogues
Coripren offers the advantage of combining two potent antihypertensive agents in a single tablet, providing a synergistic effect in lowering blood pressure. This combination therapy can enhance treatment outcomes compared to using enalapril or lercanidipine alone.
Suitable Patient Groups
Coripren tablets are suitable for adult patients with hypertension. Dosage adjustments may be necessary for elderly individuals or patients with impaired renal function. The safety and efficacy of this medication in pediatric populations have not been established.
Storage and Shelf Life
Store Coripren tablets in a cool, dry place away from direct sunlight. Keep the medication out of the reach of children and pets. Check the expiration date on the packaging and do not use the tablets beyond the specified shelf life.
Packaging Description
Coripren tablets are available in a package containing 56 coated tablets. The packaging is designed to protect the tablets from environmental factors and maintain their stability until the expiration date.
Clinical Evidence and Proven Effectiveness
Studies have demonstrated the efficacy of Coripren in managing hypertension and reducing the risk of cardiovascular events. The combination of enalapril and lercanidipine has shown significant antihypertensive effects in clinical trials. The dual action of these components makes Coripren a valuable option in the treatment of high blood pressure.
