Description
Coronal-10 (Bisoprolol) Coated Tablets 10 mg. №30
Ingredients
Active ingredient: Bisoprolol fumarate 10 mg.
Other ingredients: Microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, hypromellose, titanium dioxide, polyethylene glycol.
Mechanism of Action
Bisoprolol, the active ingredient in Coronal-10 tablets, is a selective beta-1 adrenergic receptor blocker. By blocking the effects of catecholamines like epinephrine on the heart, bisoprolol reduces heart rate, cardiac output, and myocardial oxygen demand. This leads to decreased blood pressure and improved cardiac function.
Pharmacological Properties
Bisoprolol is a cardioselective beta-blocker with high beta-1 receptor affinity. It exhibits antiarrhythmic properties, reduces sympathetic stimulation of the heart, and helps in the management of hypertension, angina pectoris, and heart failure.
Indications for Use
Coronal-10 (Bisoprolol) Coated Tablets are indicated for the treatment of hypertension, stable angina pectoris, and chronic heart failure with reduced ejection fraction.
Contraindications
Do not use Coronal-10 (Bisoprolol) Coated Tablets if:
- You are allergic to bisoprolol or any other components of the product.
- You have a history of bronchospasm or severe bradycardia.
- You are in cardiogenic shock.
Side Effects
Common side effects of Coronal-10 tablets may include bradycardia, hypotension, dizziness, fatigue, and gastrointestinal disturbances. Serious but rare side effects may include bronchospasm, heart block, and exacerbation of heart failure symptoms.
Usage Instructions
Recommended dosage: Take 1 tablet orally once daily, with or without food, or as directed by a healthcare professional. Swallow the tablet whole with a glass of water and do not crush or chew it.
Benefits Compared to Analogues
Bisoprolol has demonstrated similar efficacy to other beta-blockers in the management of hypertension and heart failure but with a potentially lower risk of adverse effects. Coronal-10 tablets offer a well-tolerated treatment option for patients requiring long-term cardiovascular therapy.
Suitable Patient Groups
Coronal-10 (Bisoprolol) Coated Tablets are suitable for adults of all age groups, including elderly patients. Use in pediatric populations should be under the guidance of a specialist.
Storage and Shelf Life
Store Coronal-10 tablets in a cool, dry place below 25°C. Keep them in the original packaging to protect from moisture. The shelf life of the product is mentioned on the packaging and should not be exceeded.
Packaging Description
Coronal-10 (Bisoprolol) Coated Tablets are supplied in blister packs of 30 tablets. Each tablet is film-coated for easy swallowing and protection from environmental factors.
Clinical Evidence and Proven Effectiveness
Bisoprolol, the active ingredient in Coronal-10 tablets, has been extensively studied in clinical trials, demonstrating its efficacy in reducing mortality and hospitalizations in heart failure patients. Research published in reputable journals has highlighted the benefits of bisoprolol in improving cardiovascular outcomes.
