Description

Dalacin С (clindamycin) capsules 300 mg. №16

Ingredients

Active ingredient: Clindamycin (as clindamycin hydrochloride).

Dosage

Recommended dosage: The usual dose is 150-450 mg every 6 hours, depending on the severity of the infection.

Indications

Indicated for: Treatment of serious infections caused by susceptible anaerobic bacteria.

Contraindications

Contraindicated in: Patients with a history of hypersensitivity to clindamycin or lincomycin.

Directions

Administration: Swallow whole with a full glass of water to avoid esophageal irritation.

Scientific Evidence

Clindamycin, the active ingredient in Dalacin C, is a lincosamide antibiotic that inhibits bacterial protein synthesis. Studies have shown its efficacy in treating various infections, including skin and soft tissue infections, respiratory tract infections, and bone and joint infections.

Additional Information

Clindamycin has been widely used in clinical practice due to its broad spectrum of activity against both aerobic and anaerobic bacteria. It is considered a first-line treatment for certain infections, especially those caused by anaerobic bacteria such as Bacteroides fragilis.

Pharmacological Effects

Clindamycin works by binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis. This action results in the suppression of bacterial growth and the eventual eradication of the infection. Additionally, clindamycin has excellent tissue penetration, making it effective in treating deep-seated infections.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of clindamycin in various infections, showing comparable or superior outcomes compared to other antibiotics. In a study by Brook, et al., clindamycin was found to be highly effective in treating skin and soft tissue infections, with a low incidence of adverse effects.

Overall, Dalacin C (clindamycin) capsules 300 mg. №16 offer a potent and reliable treatment option for a range of bacterial infections, supported by scientific evidence and clinical trials.