Description
Delagyl (Chloroquine) Tablets 250 mg. №30
Ingredients
Active ingredient: Chloroquine phosphate 250 mg.
Mechanism of Action
Chloroquine, the active ingredient in Delagyl tablets, exerts its pharmacological effects by inhibiting the growth and replication of Plasmodium species, the causative agents of malaria. It interferes with the parasites’ ability to break down and utilize hemoglobin, ultimately leading to their death.
Pharmacological Properties
Delagyl tablets containing chloroquine phosphate demonstrate antimalarial properties by disrupting the life cycle of Plasmodium species. Chloroquine also exhibits immunomodulatory effects, potentially enhancing its therapeutic benefits in the treatment of malaria and other related conditions.
Indications for Use
Delagyl tablets are indicated for the treatment and prophylaxis of malaria caused by susceptible strains of Plasmodium. It is effective in both the treatment of acute malaria infections and the prevention of relapses in individuals residing in or traveling to malaria-endemic areas.
Contraindications
Do not use Delagyl tablets if you have a known hypersensitivity to chloroquine or any other components of the formulation. Patients with a history of retinopathy, psoriasis, or porphyria should avoid the use of Delagyl due to potential exacerbation of these conditions.
Side Effects
Common side effects associated with the use of Delagyl tablets may include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Headache, dizziness, and skin reactions like itching or rash are also reported. In rare cases, chloroquine can lead to more serious adverse effects such as retinopathy or cardiomyopathy.
Usage Instructions
For malaria prophylaxis, the typical adult dosage of Delagyl is 500 mg once weekly, initiated one week prior to entering a malaria-endemic region and continued throughout the stay and for four weeks after leaving the area. Dosage adjustments may be necessary based on individual patient factors, and it is crucial to follow the healthcare provider’s instructions precisely to ensure optimal effectiveness.
Benefits Compared to Analogues
Delagyl, with its active ingredient chloroquine, offers a well-established and cost-effective option for the treatment and prevention of malaria. Compared to newer antimalarial agents, chloroquine has a long history of safe and effective use, making it a preferred choice in regions where Plasmodium species have not developed significant resistance to the drug.
Suitable Patient Groups
Delagyl tablets are suitable for a wide range of patient groups including adults, children, and the elderly. However, special caution should be exercised in certain populations such as pregnant women and individuals with pre-existing cardiac conditions or hepatic impairment. Pediatric dosages should be carefully calculated based on the child’s weight and age to prevent overdose.
Storage and Shelf Life
- Storage: Delagyl tablets should be stored at room temperature, protected from moisture and excessive heat. Avoid exposing the medication to direct sunlight or extreme environmental conditions.
- Shelf Life: Check the expiration date on the packaging before use. Do not use Delagyl tablets beyond the stated shelf life as it may lead to reduced efficacy or potential harm.
Packaging Description
Each package of Delagyl tablets contains 30 tablets, each tablet providing 250 mg of chloroquine phosphate. The packaging is designed to maintain the integrity of the tablets and protect them from environmental factors that could compromise their quality.
