Description
Denizid (Ceftazidime) Powder for Solution for Injections 1g. №1 Vial
Ingredients
Active ingredient: Ceftazidime. Inactive ingredients: Sterile water for injection.
Mechanism of Action
Ceftazidime is a third-generation cephalosporin antibiotic that exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. This mechanism leads to bacterial cell death, aiding in the treatment of infections.
Pharmacological Properties
Ceftazidime demonstrates broad-spectrum activity against many Gram-negative bacteria, making it effective in combating various infections. Its pharmacological properties include potent antibacterial action and low toxicity profile.
Indications for Use
- Treatment of infections caused by susceptible bacteria
- Lower respiratory tract infections
- Urinary tract infections
- Skin and skin structure infections
- Intra-abdominal infections
Contraindications
Contraindications: Ceftazidime should not be used in patients with a known allergy to ceftazidime or other cephalosporins. Caution is advised in patients with a history of hypersensitivity reactions to beta-lactam antibiotics.
Side Effects
Common side effects of ceftazidime may include gastrointestinal disturbances, hypersensitivity reactions, and superinfection. Monitoring for adverse reactions is essential during treatment.
Usage Instructions
Dosage: The usual adult dosage is 1g every 8 to 12 hours. Dosage adjustments may be necessary based on the severity of the infection and renal function. Ceftazidime is administered by intravenous or intramuscular injection following reconstitution as per the instructions provided.
Benefits Compared to Analogues
Ceftazidime offers advantages over some analogues due to its broad-spectrum activity and efficacy against multidrug-resistant bacterial strains. Its clinical effectiveness in treating severe infections makes it a preferred choice in certain clinical scenarios.
Suitable Patient Groups
Ceftazidime is suitable for use in adult patients, including the elderly and those with compromised renal function. Pediatric dosing should be determined based on weight and severity of the infection. Special caution is required in patients with known drug allergies.
Storage and Shelf Life
Store Denizid (Ceftazidime) according to the manufacturer’s instructions. Ensure proper storage conditions to maintain the product’s stability and efficacy. Check the expiration date on the packaging and do not use expired vials.
Packaging Description
Denizid (Ceftazidime) is available in single-dose vials containing 1g of powder for reconstitution. Each vial is intended for one-time use and should be prepared as directed before administration.
Clinical Evidence and Proven Effectiveness
Clinical studies have demonstrated the efficacy of ceftazidime in treating various infections, including hospital-acquired pneumonia and complicated urinary tract infections. Its effectiveness against multidrug-resistant strains highlights its importance in clinical practice.
