Description

Dexametazona (Dexamethasone) Phosphate Ampoules 0.4% 1ml. №10

Ingredients:

Each ampoule contains: Dexamethasone phosphate 0.4%, sodium citrate, citric acid, and water for injection.

Mechanism of Action:

Dexametazona acts as a potent synthetic glucocorticoid. It binds to specific cytoplasmic receptors and modulates the transcription of various genes involved in the inflammatory response and immune regulation.

Pharmacological Properties:

Dexametazona exhibits anti-inflammatory, immunosuppressant, and anti-allergic properties. It suppresses the migration of polymorphonuclear leukocytes and reverses increased capillary permeability.

Indications for Use:

• Inflammatory conditions
• Allergic reactions
• Certain types of arthritis
• Skin conditions
• Other conditions requiring anti-inflammatory and immunosuppressant effects

Contraindications:

Avoid using Dexametazona if:

• You are allergic to dexamethasone or any components in the formulation
• You have a systemic fungal infection
• You are receiving live vaccines

Side Effects:

Common side effects of Dexametazona may include fluid retention, changes in appetite, insomnia, mood swings, and increased susceptibility to infections. Long-term use can lead to adrenal suppression and osteoporosis.

Usage Instructions:

The typical dosage is: 1 to 2 milliliters administered intramuscularly or intravenously. Dosage should be individualized based on the specific condition. Consult a healthcare professional for personalized dosing guidance.

Benefits Compared to Analogues:

Dexametazona offers superior anti-inflammatory and immunosuppressant effects compared to many other corticosteroids. It has a longer duration of action and a lower mineralocorticoid effect, reducing the risk of electrolyte imbalances.

Suitable Patient Groups:

Dexametazona can be used in various patient populations, including adults, children, and the elderly. Dosage adjustments may be necessary in elderly patients or those with compromised renal or hepatic function.

Storage Conditions and Shelf Life:

Store Dexametazona ampoules at room temperature, protected from light and moisture. Keep out of the reach of children. Check the expiration date before use and discard any expired product.

Packaging Description:

Dexametazona ampoules are supplied in packs containing 10 ampoules, each containing 1ml of the solution. The packaging is designed to maintain sterility and protect the product from external contaminants.

Scientific Evidence:

Dexamethasone, the active ingredient in Dexametazona ampoules, has been extensively researched for its anti-inflammatory and immunomodulatory effects. Notably, studies like the RECOVERY trial have demonstrated the efficacy of dexamethasone in reducing mortality in severe cases of COVID-19 by mitigating inflammation and cytokine storm.

Additional Information:

It is crucial to adhere to proper aseptic techniques during the administration of Dexametazona to prevent contamination. For more detailed information on the use of Dexametazona ampoules, potential side effects, or drug interactions, consult a qualified healthcare provider.