Description

Diaformin SR (metformin) tablets with prolonged release 1000 mg. №60

Ingredients

Each tablet contains: Metformin Hydrochloride 1000 mg.

Dosage

Recommended dosage: The usual starting dose is 500 mg or 850 mg once daily with meals. Dosage can be adjusted based on blood glucose levels.

Indications

Indicated for: Treatment of type 2 diabetes mellitus in adults, particularly in overweight patients when dietary management and exercise alone does not result in adequate glycemic control.

Contraindications

Contraindicated in: Patients with renal impairment, acute or chronic metabolic acidosis, and hypersensitivity to metformin.

Directions

Administration: Swallow the tablets whole with a full glass of water. Do not crush or chew the tablets.

Scientific Evidence

Metformin, the active ingredient in Diaformin SR, is a first-line medication for the management of type 2 diabetes. Studies have shown that metformin works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. Research published in the Journal of Clinical Investigation has demonstrated the beneficial effects of metformin in reducing hemoglobin A1c levels and improving overall glycemic control.

Additional Information

Diaformin SR with prolonged release formulation offers the advantage of once-daily dosing, providing a steady release of metformin throughout the day. This can help in reducing gastrointestinal side effects commonly associated with immediate-release formulations. It is important to monitor renal function regularly while on metformin therapy to prevent lactic acidosis.

Metformin has been extensively studied in various clinical trials and has consistently shown effectiveness in lowering blood glucose levels and reducing the risk of diabetes-related complications. Additionally, metformin has been associated with potential cardiovascular benefits, making it a valuable treatment option for individuals with type 2 diabetes.