Description

Difliuzol (Fluconazole) Capsules 150 mg №2

Ingredients

Active ingredient: Each capsule contains 150 mg of fluconazole.

Dosage

Dosage: The usual dose is one capsule daily. Consult your healthcare provider for personalized dosing instructions.

Indications

Indications: Difliuzol (fluconazole) is indicated for the treatment of various fungal infections, including vaginal yeast infections, oral thrush, esophageal candidiasis, and cryptococcal meningitis.

Contraindications

Contraindications: Do not use Difliuzol if you are allergic to fluconazole or other azole antifungal drugs.

Directions

Directions: Swallow the capsule whole with a full glass of water. Take as directed by your healthcare provider.

Scientific Evidence

Fluconazole, the active ingredient in Difliuzol, is a potent antifungal agent that works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. This disruption leads to the death of the fungal cells, effectively treating the infection. Several studies have demonstrated the efficacy of fluconazole in treating various fungal infections, with high cure rates and minimal side effects.

Additional Information

It is important to complete the full course of treatment with Difliuzol as prescribed by your healthcare provider, even if symptoms improve before the treatment is finished. Abruptly stopping the medication can lead to the recurrence of the infection or the development of drug-resistant strains of fungi.

Pharmacological Effects

Fluconazole exerts its antifungal effects by selectively inhibiting the enzyme lanosterol 14-alpha-demethylase involved in the biosynthesis of ergosterol, a vital component of fungal cell membranes. By disrupting ergosterol synthesis, fluconazole compromises the integrity of the fungal cell membrane, leading to cell death. This targeted mechanism of action makes fluconazole highly effective against a wide range of fungal pathogens.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown fluconazole to be highly effective in the treatment of various fungal infections, with cure rates comparable to or better than other antifungal agents. In comparative studies, fluconazole has demonstrated superior efficacy in the treatment of vaginal yeast infections and invasive candidiasis compared to other antifungal medications. Its broad spectrum of activity and favorable safety profile make fluconazole a preferred choice for many healthcare providers in the management of fungal infections.

References:
1. Pappas PG, Kauffman CA, Andes DR, et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62(4):e1-e50.
2. Rex JH, Walsh TJ, Sobel JD, et al. Practice Guidelines for the Treatment of Candidiasis. Clin Infect Dis. 2000;30(4):662-678.