Description
Difors XL (Amlodipine Besilate and Valsartan) Coated Tablets 10 mg/160 mg. №10
Ingredients
Each tablet contains:
- Amlodipine besilate 10 mg
- Valsartan 160 mg
Mechanism of Action
Difors XL combines amlodipine, a calcium channel blocker, and valsartan, an angiotensin II receptor blocker. Amlodipine inhibits the influx of calcium ions into vascular smooth muscle cells, leading to vasodilation and reduced peripheral vascular resistance. Valsartan selectively blocks the binding of angiotensin II to its receptors, resulting in vasodilation and decreased aldosterone secretion. The synergistic action of these two components helps in lowering blood pressure by reducing systemic vascular resistance and improving cardiac output.
Pharmacological Properties
Difors XL exerts antihypertensive effects through the combined actions of amlodipine and valsartan. Amlodipine acts as a peripheral vasodilator by inhibiting calcium influx, while valsartan blocks angiotensin II receptors, leading to vasodilation. This dual mechanism results in effective blood pressure control and cardiovascular protection.
Indications for Use
Difors XL tablets are indicated for the treatment of hypertension in adult patients who require combination therapy for blood pressure control.
Contraindications
Do not use Difors XL if you have a history of hypersensitivity to amlodipine, valsartan, or any other components of the product. Avoid concomitant use with aliskiren in patients with diabetes or renal impairment.
Side Effects
The common side effects of Difors XL may include peripheral edema, dizziness, flushing, headache, and fatigue. In rare cases, serious adverse effects such as angioedema, hypotension, and hepatic injury may occur. Patients should seek medical attention if they experience any unusual symptoms while taking Difors XL.
Usage Instructions
The recommended dosage of Difors XL is one tablet once daily, preferably at the same time each day. The tablet should be swallowed whole with a glass of water, with or without food. Patients should adhere to the prescribed regimen and not alter the dosage without consulting a healthcare provider.
Benefits Compared to Analogues
Difors XL offers the advantage of combining two potent antihypertensive agents, amlodipine, and valsartan, in a single formulation. This combination provides synergistic effects in blood pressure reduction, offering better control compared to monotherapy with either drug alone. The convenience of a once-daily dosing regimen enhances patient compliance and simplifies treatment management.
Suitable Patient Groups
Difors XL is suitable for adult patients with hypertension who require dual therapy for optimal blood pressure control. It is not recommended for use in children, pregnant women, or individuals with severe hepatic impairment. Elderly patients may require dose adjustments based on their renal function and overall health status.
Storage and Shelf Life
Store Difors XL tablets in a cool, dry place away from direct sunlight and moisture. Keep the product out of reach of children. Check the expiration date on the packaging and do not use the tablets if past the specified shelf life.
Packaging Description
Difors XL is available in blister packs containing 10 coated tablets. Each tablet is imprinted with the product name and strength for easy identification. The packaging is designed to protect the tablets from environmental factors and maintain their stability until use.
Clinical Evidence and Proven Effectiveness
Difors XL has been evaluated in clinical trials to assess its efficacy in hypertension management. Studies have demonstrated that the combination of amlodipine and valsartan offers superior blood pressure control compared to monotherapy with either drug. The synergistic effects of these components result in improved outcomes and reduced cardiovascular risks in hypertensive patients.
