Dioxidin ampoules 1% 10 ml. №10

Description

Dioxidin ampoules Composition
active substance: dioxidine;

1 ml of solution contains 10 mg dioxidine in terms of 100% substance;

Dioxidin ampoules excipients: water for injection.

Dioxidin ampoules Dosage form
Solution.

Basic physical and chemical properties: transparent greenish-yellow liquid.

Pharmacotherapeutic group
Antibacterial agents. ATX code J01X X.

Pharmacodynamics
Dioxidine is a broad-spectrum antibacterial drug. Effective for infections caused by Proteus vulgaris, Pseudomonas aeruginosa, Friedlander’s bacillus, E. coli and dysentery bacillus, salmonella, staphylococci, streptococci, pathogenic anaerobes, including pathogens of gas gangrene. It is active against antibiotic-resistant bacterial strains, sulfonamides, nitrofurans and other drugs.

Pharmacokinetics
When applied topically, dioxidine is partially absorbed, does not have a local effect. Does not undergo metabolism. Does not cumulate. It is excreted by the kidneys.

Indications
Purulent-inflammatory processes of various localization purulent pleurisy, pleural empyema, lung abscess, peritonitis, cystitis, wounds with deep cavities, soft tissue abscesses, phlegmon, postoperative wounds in the urine and biliary tract. It is also used to prevent infectious complications after bladder catheterization.

Contraindications
Individual intolerance to the drug, insufficiency of the adrenal cortex (including a history).

Interaction with other medicinal products and other types of interactions
Not described.

Application features
Dioxidine is used in a hospital setting. Experimentally found teratogenic and embryotoxic effects (therefore, it is contraindicated in pregnancy), the drug also has a mutagenic effect. In this regard, dioxidine is prescribed only for severe forms of infectious diseases or with the ineffectiveness of other antibacterial drugs, including cephalosporins of II-IV generations, fluoroquinolones, carbapenems. Uncontrolled use of dioxidine and dosage forms that contain it is not allowed.

Use with caution in renal failure, in chronic renal failure, the dose is reduced.

When age spots appear, the duration of the dose is increased to 1.5-2 hours, the dose is reduced, antihistamines are prescribed, and, if necessary, the drug is discontinued.

The ability to influence the reaction rate when driving or operating machinery
During the period of treatment, care should be taken when driving vehicles while engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Use during pregnancy or lactation
The drug is contraindicated for use during pregnancy or lactation.

Method of administration and dosage
Dioxidine is prescribed only for adults.

Before starting the course of treatment, it is necessary to test the tolerance of the drug, for which 10 ml of a 1% solution should be injected into the purulent cavity. In the absence of side effects (dizziness, chills, fever) within 3-6 hours, course treatment is started. The solution is injected into the cavity through a drainage tube, catheter or syringe – usually 10-50 ml of a 1% solution. The maximum daily dose is 70 ml of a 1% solution. Apply 1 or 2 times a day (not exceeding a daily dose of 70 ml of a 1% solution). The duration of treatment depends on the severity of the disease and the tolerability of the drug. The course of treatment can last 3 weeks or more. If necessary, repeat the course of treatment after 1 – 1.5 months.

It is also applied topically, applying dressings moistened with a 1% solution on the wound surface.

Children
The drug is used to treat children.