Description

Diroton (Lisinopril) Tablets 20 mg. №56

Ingredients:

Each tablet contains 20 mg of lisinopril.

Mechanism of Action:

Lisinopril, an ACE inhibitor, works by inhibiting the angiotensin-converting enzyme, leading to vasodilation and reduced aldosterone secretion, thereby lowering blood pressure.

Pharmacological Properties:

Lisinopril exerts its antihypertensive effect by suppressing the renin-angiotensin-aldosterone system and promoting vasodilation. It also enhances cardiac function by reducing afterload and preload.

Indications for Use:

Diroton tablets are indicated for the treatment of hypertension and heart failure in adult patients.

Contraindications:

Avoid using Diroton if you have a known allergy to lisinopril or any other ACE inhibitors. Patients with a history of angioedema related to previous ACE inhibitor therapy should also not take Diroton.

Side Effects:

Common side effects of Diroton may include dizziness, dry cough, hyperkalemia, and hypotension. Severe allergic reactions and renal impairment are rare but serious adverse effects that may occur.

Usage Instructions:

The usual starting dose of Diroton is 10 mg once daily. Dosage adjustments should be made based on individual response. The tablets are for oral administration and can be taken with or without food as directed by a healthcare provider.

Benefits Compared to Analogues:

Diroton, containing lisinopril, offers a well-established efficacy profile in managing hypertension and heart failure. Its proven ability to reduce blood pressure, improve cardiac function, and decrease mortality rates sets it apart from other ACE inhibitors.

Suitable Patient Groups:

Diroton is suitable for adult patients with hypertension or heart failure. Special caution is advised when prescribing to elderly individuals or those with impaired renal function.

Storage Conditions and Shelf Life:

Store Diroton tablets in a cool, dry place away from direct sunlight. Keep the packaging tightly closed. The shelf life of Diroton is typically indicated on the packaging and should be checked before use.

Packaging Description:

Diroton tablets are typically packaged in blister packs containing 56 tablets. The packaging should include essential information such as the drug name, dosage strength, batch number, and expiration date.

Scientific Evidence:

Lisinopril, the active ingredient in Diroton, has been extensively studied and demonstrated efficacy in managing hypertension and heart failure. Clinical trials have shown its effectiveness in reducing blood pressure, improving cardiac function, and reducing mortality rates in heart failure patients.

Studies published in reputable journals like the New England Journal of Medicine have highlighted the cardiovascular benefits of lisinopril, including a significant reduction in cardiovascular events and stroke risk in high-risk patients.