Ditilin (suxamethonium iodide) solution for injections 20 mg/ml. 5 ml. ampoules №10

Description

Ditilin Storage
active substance: suxamethonium iodide;

1 ml of solution contains suxamethonium iodide (dithiline) 20 mg;

Ditilin Excipients: sodium chloride, edetate disodium, ascorbic acid, dilute hydrochloric acid, water for injections.

Ditilin Dosage form
Solution for injection.

Basic physical and chemical properties: transparent colorless liquid.

Pharmacotherapeutic group
Muscle relaxants. Choline derivatives. Suxamethonium.

ATX code M03A B01.

Pharmacological properties

Pharmacodynamics.

Dithiline is a short-acting depolarizing muscle relaxant. The chemical structure of dithiline can be considered as a double molecule of acetylcholine. It has a high affinity for the postsynaptic neuromuscular receptor, competitively blocks neuromuscular transmission, causes depolarization of the postsynaptic membrane and short-term skeletal muscle relaxation. It is rapidly destroyed by pseudocholinesterase with the formation of choline and succinic acid, due to which the effect of dithiline is short-lived.

After intravenous administration, the effect of the drug is manifested in 2-3 minutes and persists in full for up to 3 minutes. Approximately 5 minutes after the end of the drug, the effect completely ceases.

The rapid onset of effect and the subsequent rapid recovery of muscle tone allows you to create controlled and controlled relaxation of skeletal muscle.

Pharmacokinetics.

Data on the pharmacokinetics of dithiline are significantly limited due to the short duration of action of the drug. Immediately after intravenous administration, the drug is exposed to pseudocholinesterase in the blood. It decomposes into choline, which is then used for the synthesis of acetylcholine, and succinic acid, which is involved in tissue respiration. The drug crosses the blood-brain and placental barriers.

Indication
Use for the purpose of muscle relaxation during tracheal intubation, endoscopic procedures (broncho-, esophago-, laryngo-, cystoscopy), short-term operations requiring muscle relaxation (correction of dislocations, reposition of bone fragments), to maintain myoplegia in operative surgery. ), elimination by the court when editing.

Contraindication
Hypersensitivity to the components of the drug, glaucoma, myasthenia gravis, acute liver failure, severe anemia, history of malignant hyperthermia, atypical plasma cholinesterase activity; hyperkalemia with major injuries or burns, long-term immobilization of the patient, skeletal muscle paralysis; hyperkalaemia associated with renal failure; open eye injury and cases when the increase in intraocular pressure is undesirable; skeletal muscle myopathy, rhabdomyolysis.

Concomitant use of drugs that increase sensitivity to suxamethonium.

Interaction with other medicinal products and other forms of interaction
The following drugs and chemicals reduce the activity of cholinesterase in blood plasma, thereby increasing the intensity and duration of muscle relaxant action of Ditilin-Darnitsa. These include: organophosphorus insecticides and metrifonate; eye drops with echothiophate; trimetafan; specific anticholinesterase agents: neostigmine, pyridostigmine, physostigmine, edrofonium; tacrine hydrochloride; cytotoxic drugs: cyclophosphamide, mechlorethamine, triethylenemelamine, thiotepa; drugs used in psychiatric practice: phenelzine, propazine, chlorpromazine; anesthetic drugs: ketamine, morphine, morphine antagonists, pethidine, pancuronium, propanidide.

Other drugs that may adversely affect plasma cholinesterase activity include aprotinin, diphenhydramine, promethazine, estrogens, oxytocin, glucocorticosteroids (in high doses), oral contraceptives, terbutaline, metoclopramide.