Description

Divigel (estradiol) gel 0.1% 0.5 g. №28

Ingredients:

Each 0.5 g of Divigel contains 0.1% estradiol.

Dosage:

Apply a thin layer of Divigel once daily to the skin of the upper thigh and allow it to dry before dressing.

Indications:

Divigel is indicated for the treatment of moderate to severe vasomotor symptoms associated with menopause.

Contraindications:

Do not use Divigel in individuals with a history of breast cancer, estrogen-dependent neoplasia, undiagnosed abnormal genital bleeding, or known or suspected pregnancy.

Directions:

Before applying Divigel, ensure the skin is clean, dry, and free of lotions. Rotate application sites and avoid sun exposure to the application site.

Scientific Evidence:

Studies have shown that estradiol gel, such as Divigel, effectively reduces the frequency and severity of hot flashes and night sweats in menopausal women. The transdermal delivery of estradiol bypasses the first-pass metabolism, providing a consistent hormone level in the bloodstream.

Additional Information:

Divigel is a convenient and discreet way to administer hormone therapy for menopausal symptoms. It offers a lower risk of thrombosis compared to oral estrogen therapy. It is important to follow the prescribed dosage and application instructions to maximize the benefits of Divigel.

Research has also indicated that estradiol therapy may have positive effects on bone health and may reduce the risk of osteoporosis in postmenopausal women. Regular monitoring and consultation with a healthcare provider are recommended during hormone replacement therapy with Divigel.