Description

Divigel (Estradiol) Gel 0.1% 0.5 g. №28

Ingredients:

Each 0.5 g of Divigel contains 0.1% estradiol.

Mechanism of Action:

Divigel delivers estradiol, a form of estrogen, through the skin into the bloodstream. Estradiol binds to estrogen receptors, exerting its effects on target tissues, alleviating menopausal symptoms.

Pharmacological Properties:

• Divigel provides a controlled release of estradiol, maintaining stable hormone levels.
• The transdermal route bypasses the first-pass metabolism, ensuring efficient absorption.

Indications for Use:

Divigel is indicated for the treatment of moderate to severe vasomotor symptoms associated with menopause, such as hot flashes and night sweats.

Contraindications:

Avoid using Divigel in individuals with a history of breast cancer, estrogen-dependent neoplasia, undiagnosed abnormal genital bleeding, or known or suspected pregnancy due to potential risks.

Side Effects:

Common side effects of Divigel may include skin irritation at the application site, breast tenderness, headache, and nausea. Consult a healthcare provider if any adverse reactions occur.

Usage Instructions:

Apply a thin layer of Divigel once daily to the skin of the upper thigh. Ensure the skin is clean, dry, and free of lotions before application. Rotate application sites and avoid direct sunlight on the application area.

Benefits Compared to Analogues:

Divigel offers a convenient transdermal delivery system, reducing the risk of thrombosis associated with oral estrogen therapy. Its consistent hormone levels provide effective symptom relief with minimized side effects.

Suitable Patient Groups:

Divigel is suitable for menopausal women experiencing vasomotor symptoms. Dosage adjustment may be necessary for elderly patients or those with specific medical conditions; consult a healthcare professional for personalized recommendations.

Storage and Shelf Life:

Store Divigel at room temperature, away from moisture and heat. Check the expiration date on the packaging and do not use expired products.

Packaging Description:

Divigel is available in a package containing 28 single-dose sachets of 0.5 g gel each, ensuring convenient and hygienic usage.

Clinical Evidence and Proven Effectiveness:

Clinical studies have demonstrated that estradiol gel formulations, like Divigel, effectively reduce the frequency and severity of menopausal symptoms, providing relief to affected individuals. The transdermal delivery of estradiol ensures consistent hormone levels in circulation, enhancing therapeutic outcomes.