Description
Divigel (estradiol) gel 0.1% 1g. №28
Ingredients
Active ingredient: Estradiol 0.1%
Other ingredients: Carbomer, ethanol, propylene glycol, purified water.
Mechanism of Action
Estradiol, a synthetic form of estrogen, binds to estrogen receptors in the body, exerting estrogenic effects that help restore hormonal balance and alleviate menopausal symptoms.
Pharmacological Properties
Divigel contains estradiol, which acts as an estrogen receptor agonist, leading to the regulation of gene transcription and protein synthesis associated with estrogenic effects.
Indications for Use
Divigel is indicated for the treatment of moderate to severe vasomotor symptoms associated with menopause, such as hot flashes and night sweats.
Contraindications
Do not use Divigel in individuals with a history of estrogen-dependent tumors, undiagnosed abnormal genital bleeding, active thrombophlebitis, or during pregnancy.
Side Effects
Common side effects of Divigel may include skin irritation at the application site, breast tenderness, headache, and nausea. Serious side effects such as chest pain, vision changes, or signs of a blood clot require immediate medical attention.
Usage Instructions
Apply 1g of Divigel daily to the skin of the thigh and rub it in until dry. Rotate application sites to prevent skin irritation. Clean and dry the skin before each application and wash hands thoroughly after use.
Benefits Compared to Analogues
Compared to oral estrogen therapy, Divigel offers localized delivery of estradiol with potentially lower systemic exposure, reducing the risk of certain side effects like liver metabolism issues.
Suitable Patient Groups
Divigel is suitable for menopausal women experiencing vasomotor symptoms. Dosage adjustments may be necessary for elderly patients or those with hepatic impairment. Use in children is not recommended.
Storage and Shelf Life
Store Divigel at room temperature away from heat and moisture. Keep out of reach of children. Check the expiration date on the packaging and do not use expired product.
Packaging Description
Divigel is available in a package containing 28 single-dose packets of 1g gel each, designed for convenient and hygienic application.
Clinical Evidence and Proven Effectiveness
Clinical studies have shown that Divigel effectively reduces the frequency and severity of hot flashes and night sweats in menopausal women. Research published in the Journal of Women’s Health demonstrated a significant improvement in menopausal symptoms with estradiol gel therapy.
