Dobutamin (dobutamine) Admeda solution for infusions 250 mg. 50 ml. №1

Description

Dobutamin Composition
active substance: dobutamine;

50 ml of solution contains 280 mg of dobutamine hydrochloride (which corresponds to 250 mg of dobutamine)

Dobutamin Excipients: L-cysteine ​​hydrochloride monohydrate, sodium chloride, citric acid, sodium hydroxide, water for injection.

Dobutamin Indications.
Heart failure with low cardiac output associated with myocardial infarction, cardiomyopathies, infectious-allergic shock, cardiogenic shock, and heart surgery.

Contraindications
Hypersensitivity to dobutamine and other components of the drug.

Mechanical resistance to filling and / or emptying of the ventricle, for example, due to cardiac tamponade, constrictive pericarditis, hypertrophic obstructive cardiomyopathy, severe aortic stenosis; hypovolemic conditions; simultaneous use of MAO inhibitors (MAO).

Dobutamine-loaded echocardiography: history of hypersensitivity to dobutamine and concomitant use of MAO. When using atropine, it is necessary to take into account the contraindications to its use.

Dobutamine should not be used for diagnostic testing of myocardial ischemia as part of an echocardiographic study in the following cases: recent myocardial infarction (within 30 days after myocardial infarction); unstable angina pectoris stenosis of the main left coronary artery; severe hemodynamic obstruction of the outflow of the left ventricle, including hypertrophic obstructive cardiomyopathy; hemodynamic pronounced damage to the heart valve; severe heart failure (NYHA grade III or IV); a tendency to arrhythmias or a history of clinically existing or chronic arrhythmias, especially recurrent persistent ventricular tachycardia, significant conduction disturbance, acute pericarditis, myocarditis, or endocarditis; aortic dissection aortic aneurysm; weak ultrasound images inadequate treatment or control of increased blood pressure; obstruction of ventricular filling (stenosing pericarditis, pericardial tamponade) hypovolemia.

Method of administration and dosage.
The dose of dobutamine must be adjusted individually. The speed and duration of drug administration depends on the patient’s response to treatment and the occurrence of side effects. In cases of continuous administration for more than 72 hours, tolerance to the drug may occur and, in this regard, it becomes necessary to increase the dose.

It is recommended to gradually reduce the dose before stopping the administration of the drug.

Adults. Most patients respond to doses ranging from 2.5 to 10 mcg / kg / min.

In some cases, the dose of dobutamine can reach 40 mcg / kg / min.

Children. Dobutamine can be used to treat children of any age. It is recommended to start the administration with a dose of 2.5-5 mcg / kg / min, gradually increasing it to a maximum of 15 mcg / kg / min, depending on the effect.

There is evidence that the minimum effective dose for children is higher and the maximum tolerated dose is lower than for adults, so care should be taken when giving high doses to children. Most side effects, especially tachycardia, are observed with the use of dobutamine in children at doses greater than 7.5 μg / kg / min. Taking into account the narrow therapeutic dose range, the selection of the required dose of the drug for children should be very careful.

Mode of application.

Dobutamine Admed in the form of 50 ml solution for infusion (1 ampoule) can be used undiluted when using continuous infusion pumps. If necessary, the drug can be additionally diluted before administration in 5% glucose solution, 0.9% sodium chloride solution or Ringer’s solution with lactate.

Dobutamine Admeda can only be administered as an intravenous infusion. Since dobutamine has a short half-life, the drug must be administered continuously. Once reconstituted, the drug is administered through an intravenous needle or catheter using an infusion set or other dose-measuring device. To ensure dosing accuracy, high concentrations of dobutamine should only be administered through an infusion pump.

Children.
Dobutamine Admeda can be used to treat children of any age.