Doxiciclin (doxycycline) capsules 0.1 №10

Description

Doxiciclin 0.1 Storage
active substance: doxycycline;

1 capsule contains doxycycline hyclate in terms of doxycycline – 100 mg;

Doxiciclin 0.1 excipients: lactose monohydrate, calcium stearate; the capsules contain the dye Yellow West FCF (E 110).

Doxiciclin 0.1 Dosage form
Capsules.

Main physical and chemical properties: hard capsules with a lid and a yellow body, which contain powder or mass in the form of a partially or completely formed yellow column with a greenish tinge. White patches are allowed.

Pharmacotherapeutic group
Antibacterial agents for systemic use. Tetracyclines. Doxycycline.

ATX code J01A A02.

Pharmacological properties

Pharmacodynamics.

Doxycycline is a semi-synthetic antibiotic of the broad-spectrum tetracycline group. Causes bacteriostatic action by inhibiting the synthesis of protein pathogens by blocking the binding of aminoacyl-transport RNA (tRNA) with the complex “information RNA (mRNA) – ribosome”.

Active against gram-positive bacteria: aerobic cocci – Staphylococcus spp. (including those that produce penicillinase), Streptococcus spp. (including Streptococcus pneumoniae); aerobic spore-forming bacteria – Bacillus anthracis; aerobic non-spore-forming bacteria – Clostridium spp. Doxycycline is also active against gram-negative bacteria: aerobic cocci – Neisseria gonorrhoeae; aerobic bacteria – Escherichia coli; Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis, as well as against Rickettsia spp., Treponema spp., Mycoplasma spp., Chlamydia spp.

Pseudomonas aeruginosa, Proteus spp., Serratia spp., Most strains of Bacteroides fragilis are resistant to doxycycline.

Pharmacokinetics.

The drug is rapidly absorbed from the digestive tract and slowly excreted from the body. Studies show that the absorption of doxycycline is different from some other tetracyclines, it is not affected by concomitant consumption of food (including milk).

Depending on the dose, the therapeutic concentration in the blood is maintained for 18-24 hours. Binds to blood proteins by 80-90%. It is rapidly distributed in most body fluids, including bile, paranasal sinuses, pleural, synovial, and ascitic fluids. The concentration in the cerebrospinal fluid varies and after parenteral administration may be 10-25% of the concentration in the serum. The half-life of the drug is 12-22 hours. A significant part is excreted unchanged in the feces, about 40% – in the urine.

Indication
Treatment of infections caused by susceptible strains of gram-positive and gram-negative microorganisms and some other microorganisms, namely:

respiratory tract infections: pneumonia and other diseases of the lower respiratory tract caused by susceptible strains of Streptococcus pneumoniae, Haemophilus influenza, Klebsiella pneumoniae; pneumonia caused by Mycoplasma pneumoniae; chronic bronchitis, sinusitis;
urinary tract infections: infections caused by susceptible strains of Klebsiella, Enterobacter, as well as bacteria Escherichia coli, Streptococcus faecalis;
sexually transmitted infections:
– infections caused by Chlamydia trachomatis, including uncomplicated urethral and endocervical infections and rectal infections;

– non-gonococcal urethritis caused by Ureaplasma urealyticum (T-mycoplasma);

– soft chancre, inguinal granuloma, venereal granuloma;

– the drug is an alternative for the treatment of gonorrhea and syphilis;

skin infections: acne if you need antibiotics.
Treatment of infections caused by microorganisms sensitive to tetracyclines, namely:

ophthalmic infections: infections caused by susceptible bacteria Gonococci, Staphylococci and Haemophilus influenza. Infection that causes trachoma is not always eliminated, which is confirmed by immunofluorescence analysis. For the treatment of paratrachoma, the drug can be used as monotherapy or in combination with other drugs;
rickettsial infections: typhus group, rocky mountain spotted fever, Ku fever, tick-borne fever, endocarditis caused by Coxiella;
other infections: ornithosis, brucellosis (when used in combination with streptomycin), cholera, bubonic plague, epidemic relapsing fever, tick-borne relapsing fever, tularemia, melioidosis; tropical malaria resistant to chloroquine and acute intestinal amebiasis (when used in combination with an amebicide).
Alternative treatment of leptospirosis, gas gangrene, tetanus.

Prevention of the following conditions: Japanese river fever, traveler’s diarrhea (caused by enterotoxic Escherichia coli), leptospirosis, malaria. Malaria prevention should be carried out in accordance with current practice due to the possibility of developing resistance.

Contraindication
Hypersensitivity to tetracyclines, doxycycline and other components of the drug;
porphyria;
severe liver failure;
leukopenia.