Description

Doxorubicin Amaxa (doxorubicin) solution for injections 2 mg/ml. 25 ml. vial №1

Ingredients

Active ingredient: Doxorubicin hydrochloride. Inactive ingredients may include hydrochloric acid, sodium chloride, and water for injection.

Dosage

Dosage: The usual dose ranges from 60 to 75 mg/m² of body surface area, administered as a single intravenous injection every 21 to 28 days.

Indications

Indications: Doxorubicin Amaxa is indicated for the treatment of various types of cancers, including breast cancer, lung cancer, and ovarian cancer.

Contraindications

Contraindications: Do not use Doxorubicin Amaxa in patients with severe myelosuppression, severe hepatic impairment, or a history of severe hypersensitivity reactions to doxorubicin.

Directions

Administration: Doxorubicin Amaxa is administered intravenously by a healthcare professional. It is important to follow the recommended dosage and administration guidelines.

Scientific Evidence

Doxorubicin, the active ingredient in Doxorubicin Amaxa, is a widely studied anthracycline chemotherapy agent known for its efficacy in treating various cancers. Research studies have shown that doxorubicin works by intercalating into DNA strands, inhibiting topoisomerase II, and generating free radicals that cause DNA damage in cancer cells, ultimately leading to cell death.

Additional Information

In clinical trials, Doxorubicin Amaxa has demonstrated significant antitumor activity in both solid tumors and hematologic malignancies. Its use is often associated with dose-dependent cardiotoxicity, necessitating close monitoring of cardiac function during treatment. Patients should be informed about the potential side effects and the need for regular cardiac assessments.

Overall, Doxorubicin Amaxa is a valuable chemotherapy option with well-established efficacy in various cancers. Its mechanism of action, supported by scientific evidence, highlights its importance in cancer treatment regimens. Consult with healthcare professionals for personalized treatment recommendations and monitoring during therapy with Doxorubicin Amaxa.