Description

Drotaverin Tablets 0.04 g. №20

Ingredients

Each tablet contains 0.04 g of Drotaverine hydrochloride as the active ingredient.

Dosage

The usual dose is one tablet (40 mg) taken three times a day. It is important to follow the dosage instructions provided by your healthcare provider.

Indications

Drotaverin tablets are indicated for the treatment of smooth muscle spasms. They are commonly used to relieve pain and discomfort associated with conditions like irritable bowel syndrome and menstrual cramps.

Contraindications

Do not use Drotaverin tablets if you are allergic to Drotaverine or any other ingredients in the product. It is also contraindicated in patients with severe hepatic or renal impairment.

Directions

Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. Take the medication as prescribed by your doctor.

Scientific Evidence

Drotaverine is a smooth muscle relaxant that works by inhibiting phosphodiesterase enzyme activity, leading to relaxation of smooth muscles. Several studies have demonstrated the efficacy of Drotaverin in relieving smooth muscle spasms with minimal side effects. For example, a study published in the Journal of Gastroenterology and Hepatology showed that Drotaverin effectively reduced colonic spasm in patients with irritable bowel syndrome.

Additional Information

Drotaverin tablets are well-tolerated by most patients and are considered safe for short-term use. However, it is important to consult with a healthcare provider before starting any new medication, especially if you have underlying medical conditions or are taking other medications concurrently.

Pharmacological Effects: Drotaverine acts directly on smooth muscles, causing relaxation without affecting the normal peristalsis of the gastrointestinal tract. This mechanism of action makes it an effective treatment for various conditions characterized by smooth muscle spasms.

Clinical Trials: Clinical trials have shown that Drotaverin is as effective as other commonly used antispasmodic agents but with a lower incidence of side effects. A study published in the European Journal of Gastroenterology & Hepatology compared the efficacy of Drotaverin with hyoscine butylbromide in the treatment of irritable bowel syndrome and found similar symptom relief with both medications.