Description

Dufalak (lactulose) syrup 667 mg/1 ml. sackets 15 ml. №10

Ingredients

Active ingredient: Each 1 ml of Dufalak syrup contains 667 mg of lactulose.

Dosage

Dosage: The usual adult dose is 15-30 ml daily, adjusted according to individual response.

Indications

Indications: Dufalak is indicated for the treatment of constipation and hepatic encephalopathy.

Contraindications

Contraindications: Do not use Dufalak in patients with galactosemia or a history of sensitivity to lactulose.

Directions

Directions: Shake well before use. Take orally, with or without food. Follow the dosage instructions provided by your healthcare provider.

Scientific Evidence

Dufalak works by drawing water into the colon, softening the stool and increasing bowel movements. Studies have shown that lactulose is effective in treating chronic constipation by improving stool frequency and consistency. Additionally, lactulose is commonly used in the management of hepatic encephalopathy due to its ability to reduce ammonia levels in the colon.

Additional Information

It is important to drink an adequate amount of water while taking Dufalak to prevent dehydration. Avoid using other laxatives or stool softeners without consulting a healthcare professional. If symptoms persist, seek medical advice.

Pharmacological Effects: Lactulose, the active ingredient in Dufalak, is a synthetic disaccharide that is not absorbed in the small intestine but is fermented by colonic bacteria. This fermentation process leads to the production of short-chain fatty acids and lactic acid, which acidify the colonic contents, promoting the growth of beneficial bacteria and softening the stool.

Clinical Trials: Clinical trials have demonstrated the efficacy of lactulose in the treatment of constipation and hepatic encephalopathy. A study published in the American Journal of Gastroenterology found that lactulose significantly improved stool frequency and consistency in patients with chronic constipation. Another study in the New England Journal of Medicine showed that lactulose reduced blood ammonia levels and improved mental status in patients with hepatic encephalopathy.