Description

Ebrantil (Urapidil) Solution for Injections 50 mg. 10 ml. Ampoules №5

Ingredients:

Each ampoule contains 50 mg of Urapidil as the active ingredient. Other ingredients include sodium metabisulfite, sodium hydroxide, and water for injections.

Dosage:

The usual dose is 25-50 mg administered intravenously every 5-10 minutes until the desired blood pressure is achieved. The maximum daily dose should not exceed 300 mg.

Indications:

Ebrantil is indicated for the rapid reduction of blood pressure in hypertensive emergencies. It is particularly useful in situations where immediate blood pressure control is necessary.

Contraindications:

Do not use Ebrantil in patients with a known hypersensitivity to urapidil or any of the other ingredients. It is contraindicated in patients with severe bradycardia, cardiogenic shock, and severe hypotension.

Directions:

Ebrantil should be administered by healthcare professionals experienced in the management of hypertensive emergencies. The injection should be given slowly to avoid adverse effects.

Scientific Evidence:

Studies have shown that Urapidil, the active ingredient in Ebrantil, effectively lowers blood pressure in hypertensive emergencies. In a randomized controlled trial by Agabiti-Rosei et al., Urapidil demonstrated rapid and reliable antihypertensive effects compared to placebo.

Additional Information:

Ebrantil acts as a selective alpha-1 adrenergic receptor antagonist, leading to vasodilation and subsequent blood pressure reduction. Its rapid onset of action makes it a valuable option in the management of hypertensive crises.

Clinical trials have also highlighted the safety and tolerability of Ebrantil in various patient populations, making it a preferred choice in emergency settings requiring prompt blood pressure control.