$5.92
Manufacturer: Portugal
It is recommended as a dietary Supplement to the diet as an additional source of vitamins and minerals for the purpose of: prevention of toxicosis in pregnant women prevention of birth defects (malformations) of the fetus caused by a deficiency of vitamins and minerals; prevention of anemia in pregnant women providing essential vitamins and minerals to women in preparation for pregnancy, pregnancy and lactation.
Description
Emlodin Storage
active substance: 1 tablet contains 2.5 mg or 5 mg or 10 mg of amlodipine (corresponding to
3.475 mg or 6.95 mg or 13.9 mg of amlodipine besylate, respectively);
Emlodin Excipients: microcrystalline cellulose, sodium starch glycolate (type A), colloidal anhydrous silica, magnesium stearate.
Emlodin Dosage form
Tablets.
Basic physical and chemical properties:
2.5 mg tablets – white or almost white or yellowish-white, round, flat with a bevelled tablet, engraved with the stylized letter E on one side and the number 251 on the other side, without or almost odorless;
5 mg tablets – white or almost white or yellowish-white, round, flat with a bevelled tablet, engraved with the stylized letter E on one side and the number 252 on the other side, without or almost odorless;
10 mg tablets – white or almost white or yellowish-white, round, bevelled tablets, engraved with the stylized letter E on one side and the number 253 on the other side, without or almost odorless.
Pharmacotherapeutic group
Selective calcium antagonists with a predominant effect on blood vessels. Code ATX C08C A01.
Pharmacological properties
Pharmacodynamics.
Amlodipine is a calcium antagonist (a derivative of dihydropyridine) that blocks the entry of calcium ions into the myocardium and smooth muscle cells.
The mechanism of hypotensive action of amlodipine is due to the direct relaxing effect on vascular smooth muscle. The exact mechanism of the antianginal effect of amlodipine is insufficiently defined, but the following effects play a role.
Indication
Hypertension.
Chronic stable angina.
Vasospastic angina (Princemetal angina).
Contraindication
Hypersensitivity to dihydropyridines, amlodipine or to any other component of the drug is known.
Severe hypotension.
Shock (including cardiogenic shock).
Obstruction of the excretory tract of the left ventricle (eg, severe aortic stenosis).
Hemodynamically unstable heart failure after acute myocardial infarction.
Overdose
Experience with intentional drug overdose is limited.
Symptoms of overdose: the available information suggests that a significant overdose of Emlodin® will lead to excessive peripheral vasodilation and possibly to reflex tachycardia. Significant and possibly prolonged systemic hypotension, including fatal shock, has been reported.
Treatment: Clinically significant hypotension due to amlodipine overdose requires active cardiovascular support, including frequent monitoring of cardiac and respiratory function, lower extremity lift, circulating fluid volume, and urinary monitoring.
To restore vascular tone and blood pressure, you can use vasoconstrictors, making sure there are no contraindications to their use. Intravenous calcium gluconate may be useful in counteracting the effects of calcium channel blockade.
In some cases, gastric lavage may be helpful. The use of activated charcoal in healthy volunteers for 2 hours after administration of 10 mg of amlodipine significantly reduced the level of its absorption.
Because amlodipine is highly protein bound, the effect of dialysis is negligible.
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