Description
Enalozid (Enalapril, Hydrochlorothiazide) Tablets 25 mg. №20
Composition
Each tablet contains: Enalapril 20 mg and Hydrochlorothiazide 5 mg.
Mechanism of Action
Enalozid tablets combine the antihypertensive effects of enalapril, an ACE inhibitor, with the diuretic properties of hydrochlorothiazide. This combination works synergistically to reduce blood pressure by inhibiting the renin-angiotensin-aldosterone system and promoting diuresis.
Pharmacological Properties
The ACE inhibitor, enalapril, blocks the conversion of angiotensin I to angiotensin II, leading to vasodilation and decreased aldosterone secretion. Hydrochlorothiazide, a thiazide diuretic, acts on the distal convoluted tubule to increase sodium and water excretion, further reducing blood volume and pressure.
Indications for Use
Enalozid tablets are indicated for the treatment of hypertension when blood pressure is not adequately controlled with either enalapril or hydrochlorothiazide alone. It is suitable for patients requiring dual therapy to achieve optimal blood pressure control.
Contraindications
Do not use Enalozid tablets if:
- You are allergic to enalapril, hydrochlorothiazide, or any other ingredients in the product.
- You have a history of angioedema related to previous treatment with ACE inhibitors.
- You have severe renal impairment.
Side Effects
Common side effects of Enalozid may include dizziness, hypotension, dry cough, electrolyte imbalances, and renal dysfunction. Patients should report any unusual symptoms to their healthcare provider.
Usage Instructions
The recommended dosage: Take 1 tablet daily or as directed by a healthcare professional. Swallow the tablet whole with a glass of water. It can be taken with or without food. Follow the instructions provided by your healthcare provider for optimal results.
Benefits Compared to Analogues
Enalozid offers the advantage of dual therapy in a single tablet, providing the combined benefits of an ACE inhibitor and a diuretic. This simplifies treatment regimens and enhances patient compliance compared to separate administration of enalapril and hydrochlorothiazide.
Suitable Patient Groups
Enalozid is suitable for adult patients with hypertension requiring dual therapy. It may also be used in specific patient populations such as the elderly and individuals with comorbid conditions like diabetes, as determined by a healthcare provider.
Storage Conditions and Shelf Life
Store Enalozid tablets in a cool, dry place away from direct sunlight. Keep the product out of reach of children. Check the expiration date on the packaging and do not use the tablets after the specified shelf life.
Packaging Description
Enalozid tablets are available in blister packs of 20 tablets each. The packaging is designed to protect the tablets from moisture and maintain their integrity until use.
Clinical Evidence and Proven Effectiveness
Enalozid tablets have been evaluated in clinical trials for their efficacy in managing hypertension. Studies have shown a significant reduction in both systolic and diastolic blood pressure with the combination of enalapril and hydrochlorothiazide compared to placebo. The therapy has been well-tolerated with a low incidence of adverse effects.
