Description
Enap (Enalapril Maleate) Tablets 20 mg. №20
Composition
Active ingredient: Enalapril maleate 20 mg per tablet.
Mechanism of Action
Enap contains enalapril maleate, an angiotensin-converting enzyme (ACE) inhibitor. Enalapril works by inhibiting ACE, which leads to decreased production of angiotensin II, a potent vasoconstrictor. This results in vasodilation, reduced aldosterone secretion, and ultimately lowers blood pressure.
Pharmacological Properties
Enalapril maleate is rapidly absorbed after oral administration, with peak plasma concentrations reached within about one hour. It is primarily excreted unchanged in the urine. Enap has a half-life of approximately 11 hours, allowing for once-daily dosing.
Indications for Use
Indications: Enap is indicated for the treatment of hypertension, heart failure, and to improve survival following a myocardial infarction (heart attack).
Contraindications
Contraindications: Enap should not be used in patients with a known hypersensitivity to enalapril or other ACE inhibitors. It is contraindicated in patients with a history of angioedema associated with ACE inhibitor therapy.
Side Effects
Common side effects of Enap may include dizziness, cough, hypotension, and hyperkalemia. Rare but serious side effects may include angioedema, renal impairment, and neutropenia. Patients should seek medical attention if they experience any severe or persistent side effects.
Usage Instructions
Dosage: The usual dose of Enap is 20 mg taken orally once daily. Dosage may be adjusted by a healthcare provider based on individual patient response and tolerability. Enap tablets should be swallowed whole with a glass of water.
Benefits Compared to Analogues
Enap, with enalapril maleate as the active ingredient, offers comparable efficacy to other ACE inhibitors in the management of hypertension and heart failure. Its once-daily dosing regimen provides convenience and improved adherence for patients.
Suitable Patient Groups
Enap is suitable for adult patients with hypertension, heart failure, or a history of myocardial infarction. It may also be used in specific pediatric cases under the guidance of a pediatric cardiologist. Elderly patients should be monitored closely for signs of hypotension and renal function.
Storage and Shelf Life
Enap tablets should be stored at room temperature (20-25°C) away from moisture and heat. The shelf life of Enap is typically 2 years from the manufacturing date. Do not use the product after the expiry date printed on the packaging.
Packaging Description
Each package of Enap contains 20 tablets, with each tablet containing 20 mg of enalapril maleate. The tablets are typically packaged in a blister pack to protect them from external factors and maintain their stability.
Clinical Evidence and Proven Effectiveness
Enalapril, the active ingredient in Enap, has been extensively studied in clinical trials. These studies have demonstrated the efficacy of enalapril in reducing blood pressure, improving cardiac function, and enhancing survival rates in patients with hypertension and heart failure. Enap has shown consistent benefits in managing cardiovascular conditions and improving patient outcomes.
