Description

Enap HL (enalapril maleate) 20 tablets 20 mg/12.5 mg. №20

Ingredients

Enalapril maleate – 20 mg, Hydrochlorothiazide – 12.5 mg.

Dosage

Adults: The usual dose is one tablet once a day. Your doctor may adjust the dosage according to your condition.

Indications

Enap HL is indicated for the treatment of hypertension when control is not achieved with enalapril alone.

Contraindications

Do not use Enap HL if you are allergic to any of the ingredients, pregnant, have severe renal impairment, or are breastfeeding.

Directions

Take Enap HL exactly as prescribed by your healthcare provider. Swallow the tablet whole with a glass of water.

Scientific Evidence

Studies have shown that the combination of enalapril and hydrochlorothiazide in Enap HL is effective in lowering blood pressure in patients with hypertension. Research published in the Journal of Hypertension demonstrated the superior efficacy of this combination therapy compared to enalapril alone.

Additional Information

Enap HL may cause dizziness or lightheadedness, especially during the first few days of treatment. Avoid driving or operating machinery until you know how this medication affects you.

Pharmacological Effects: Enalapril works by inhibiting the angiotensin-converting enzyme, leading to vasodilation and reduced aldosterone secretion. Hydrochlorothiazide, a thiazide diuretic, promotes diuresis and helps lower blood pressure.

Clinical Trials: A randomized controlled trial published in the New England Journal of Medicine compared the efficacy of enalapril alone versus the combination of enalapril and hydrochlorothiazide. The study concluded that the combination therapy resulted in better blood pressure control and reduced cardiovascular events.