Description

Enbrel (Ethanercept) Solution for Injections 50 mg/ml. 1ml. №4

Ingredients

Active ingredient: Ethanercept
Other ingredients: Mannitol, sucrose, sodium chloride, sodium phosphate, and polysorbate 80.

Dosage

The recommended dosage: The usual dose is 50 mg once a week, administered as a subcutaneous injection.

Indications

Enbrel is indicated for: Rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.

Contraindications

Do not use Enbrel if: You are allergic to ethanercept or any components of the product.

Directions

Administer Enbrel: Subcutaneously. Follow the instructions provided in the package insert.

Scientific Evidence

Enbrel works by inhibiting tumor necrosis factor (TNF), a key player in the inflammatory response. Clinical trials have shown significant improvement in symptoms and disease progression in patients with rheumatoid arthritis and other autoimmune conditions. Research published in the New England Journal of Medicine demonstrated the efficacy of Enbrel in reducing joint damage and improving physical function in patients with rheumatoid arthritis.

Additional Information

Enbrel has been extensively studied in various patient populations, with consistent results in reducing inflammation and improving quality of life. It is considered a first-line treatment for many autoimmune conditions due to its proven efficacy and safety profile. Regular monitoring is essential to ensure optimal response and minimize potential side effects.

Pharmacological Effects: Enbrel acts by binding to TNF, preventing it from triggering inflammation and joint damage. This mechanism helps to alleviate symptoms and slow disease progression in autoimmune conditions.

Clinical Trials: A study published in Arthritis & Rheumatism compared the effectiveness of Enbrel with traditional disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis. The results showed superior clinical outcomes and improved quality of life in patients treated with Enbrel.