Description
Endoxan (Cyclophosphamide) Powder for Solution for Injections 200 mg. №10 Vial
Ingredients:
Each vial contains 200 mg of cyclophosphamide as the active ingredient.
Mechanism of Action:
Cyclophosphamide, the active ingredient in Endoxan, is an alkylating agent that exerts its cytotoxic effects by cross-linking DNA strands, ultimately inhibiting cell division and leading to cell death. This mechanism disrupts the growth and spread of cancer cells in the body.
Pharmacological Properties:
Endoxan (cyclophosphamide) belongs to the class of nitrogen mustards and is metabolized in the liver to active alkylating metabolites. It has immunosuppressive and antineoplastic properties, making it effective in the treatment of various cancers and autoimmune diseases.
Indications for Use:
Endoxan (cyclophosphamide) is indicated for the treatment of leukemia, lymphoma, multiple myeloma, and certain autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus.
Contraindications:
Endoxan (cyclophosphamide) is contraindicated in individuals with a history of severe allergic reactions to cyclophosphamide or any components of the product. It should not be used in patients with active infections, severe bone marrow suppression, or pregnancy.
Side Effects:
Common side effects of Endoxan include nausea, vomiting, myelosuppression, alopecia, and an increased susceptibility to infections. Regular monitoring and supportive care are essential to manage these adverse effects.
Usage Instructions:
Endoxan (cyclophosphamide) should be administered intravenously by healthcare professionals experienced in handling cytotoxic agents. The dosage and administration schedule are individualized based on the patient’s condition, response to treatment, and overall health status.
Benefits Compared to Analogues:
Endoxan has demonstrated efficacy in various malignancies and autoimmune diseases, offering a broad spectrum of therapeutic applications compared to other alkylating agents. Its well-established safety profile and proven clinical outcomes make it a preferred choice in many treatment regimens.
Suitable Patient Groups:
Endoxan can be used in pediatric and adult populations, including elderly patients, under close medical supervision. Dose adjustments may be necessary in individuals with compromised renal or hepatic function to prevent potential toxicity.
Storage and Shelf Life:
- Store Endoxan (cyclophosphamide) vials in a cool, dry place away from direct sunlight.
- Protect from moisture and store at controlled room temperature.
- Check the expiration date on the packaging and do not use expired products.
Packaging Description:
Each package of Endoxan contains 10 vials, each vial holding 200 mg of cyclophosphamide powder for reconstitution. The vials are made of glass and are sealed to ensure product integrity.
