Description

Envarsus (tacrolimus) tablets with prolonged release 1 mg. №60

Ingredients

Active ingredient: Tacrolimus
Other ingredients: lactose monohydrate, hypromellose, croscarmellose sodium, magnesium stearate, and more.

Dosage

Dosage: The usual starting dose of Envarsus tablets is 0.1 to 0.15 mg/kg once daily. Dosage adjustments may be needed based on blood levels and clinical condition.

Indications

Indicated for: Prevention of organ rejection in adult kidney or liver transplant patients.

Contraindications

Contraindications: Hypersensitivity to tacrolimus or any component of the formulation.

Directions

Directions: Take Envarsus tablets exactly as prescribed by your healthcare provider. Swallow the tablet whole with a glass of water.

Scientific Evidence

Pharmacological Effects: Tacrolimus is a calcineurin inhibitor that suppresses the immune system by inhibiting T-lymphocyte activation. This action helps prevent organ rejection in transplant patients.

Clinical Trials: Clinical trials have shown that Envarsus tablets with prolonged release provide effective immunosuppression with once-daily dosing, leading to improved patient adherence and outcomes compared to immediate-release formulations.

Additional Information

It is important to monitor tacrolimus blood levels regularly to ensure therapeutic efficacy and prevent toxicity. Avoid grapefruit and grapefruit juice while taking Envarsus tablets as they can increase tacrolimus levels in the blood.

Discuss with your healthcare provider about any other medications, supplements, or herbal products you are taking before starting Envarsus to prevent potential drug interactions.