Essentiale forte N capsules №30

Description

Essentiale forte N Composition
active substance: “Essential phospholipids” ® = EPL®-substance (phospholipids from soybeans ((3-sn-phosphatidyl) choline), which contain al-rac-a-tocopherol);

1 capsule contains “Essential phospholipids” ® = EPL® – substance (phospholipids from soybeans ((3-sn-phosphatidyl) choline), which contain al-rac-a-tocopherol) – 300 mg;

excipients: solid fat, refined soybean oil, hydrogenated castor oil, ethanol 96%, ethyl vanillin, 4-methoxyacetophenone, empty capsule: gelatin, purified water, titanium dioxide (E 171), iron oxide yellow (E172), iron oxide black (E172), iron oxide red (E172), sodium lauryl sulfate.

Essentiale forte N Dosage form
Capsules.

Basic physical and chemical properties: opaque, oblong, hard khaki capsules with a pasty content similar to honey.

Pharmacological group
Hepatotropic drugs. ATX code A05B A.

Pharmacological properties
Pharmacodynamics. In liver diseases, the membranes of hepatocytes and their organelles are always damaged, which can lead to a change in the activity of membrane-bound enzymes and receptor systems, a violation of the metabolic function of the cell and a decrease in the intensity of liver regeneration.

Phospholipids contained in Essentiale® forte N are similar in chemical structure to endogenous phospholipids, but have a much higher content of polyunsaturated (essential) fatty acids. These high-energy molecules are incorporated predominantly into the structures of cell membranes and facilitate the repair of damaged liver tissue. Since the cis-double bonds of these polyenoic acids prevent the parallel arrangement of the hydrocarbon chains of membrane phospholipids, the density of the arrangement of phospholipid structures decreases, as a result of which the rate of intake and excretion of substances increases. Membrane-bound enzymes form functional units that can enhance their activity and ensure the physiological course of basic metabolic processes.

Phospholipids affect the disturbed lipid metabolism by regulating lipoprotein metabolism, as a result of which neutral fats and cholesterol are converted into forms suitable for transport, especially due to an increase in the ability of high density lipoproteins (HDL) to bind cholesterol, and are directed for further oxidation. With the removal of phospholipids through the biliary tract, the lithogenic index decreases and bile stabilizes.

Pharmacokinetics. When taken orally, more than 90% of the drug is absorbed in the small intestine. The main amount is cleaved by phospholipase-A to 1 acyl-lyso-phosphatidylcholine, 50% of which is immediately reactivated into polyunsaturated phosphatidylcholine even during absorption in the small intestine. Polyunsaturated phosphatidylcholine enters the bloodstream through the lymphatic pathways and then, mainly in combination with HDL, is transported to the liver. The maximum content of phosphatidylcholine in the blood 6-24 hours after ingestion averages 20%.

The half-life of the choline component is 66 hours, for saturated fatty acids – 32 hours. In the course of kinetic studies in the human body, less than 5% of each of the introduced isotopes 3H and 14C was excreted in the feces.

Essentiale forte N Indications
Non-alcoholic steatohepatitis, alcoholic steatohepatitis, acute and chronic hepatitis of various etiologies, liver cirrhosis, pre- and postoperative treatment for surgical intervention on the liver and biliary tract, psoriasis, radiation syndrome.

Contraindications
Hypersensitivity to the components of the drug.

Interaction with other medicinal products and other forms of interaction
There are no data on incompatibility or interaction of Essentiale® forte N with other drugs.

Interaction of Essentiale® forte N, 300 mg capsules, and anticoagulants cannot be ruled out. Due to this, it may be necessary to adjust the dose of this medication.