Eutirox (levothyroxine sodium) tablets 100 mcg. №100

Description

Eutirox 100 mcg. Composition
active substance: sodium levothyroxine;

1 tablet contains levothyroxine 25 mcg or 50 mcg or 75 mcg or 100 mcg or 125 mcg or 150 mcg;

excipients: mannitol (E 421); corn starch; gelatin; croscarmellose sodium; citric acid, magnesium stearate.

Eutirox 100 mcg. Dosage form
Pills.

Basic physical and chemical properties: almost white, round, flat on both sides, with beveled edges of the tablet, with a notch for dividing on both sides, engraved on one side with the signs “EM + dispensing”.

Eutirox 100 mcg. Pharmacological group
Hormone preparations for systemic use (with the exception of sex hormones and insulin). Drugs for the treatment of thyroid diseases. Thyroid drugs. Levothyroxine sodium. ATX code N0ZA A01.

Pharmacological properties
Pharmacodynamics. Synthetic levothyroxine, which is contained in Eutirox, exhibits effects identical to those of the hormone secreted by the thyroid gland. It turns into T3 (triiodothyronine) in peripheral organs, and as an endogenous hormone affects T3 receptors. There is no difference between the functions of endogenous hormone and exogenous levothyroxine.

Pharmacokinetics. After oral administration, levothyroxine is almost completely absorbed in the upper small intestine. Depending on the galenic form of the drug, up to 80% of the dose taken is absorbed. The maximum concentration (Tmax) reaches after about 5-6 hours.

The clinical effect of the drug is manifested 3-5 days after ingestion. Levothyroxine quickly binds to specific transport proteins in the blood (up to 99.97%). The bond with proteins is not covalent, therefore, the hormone, which is in the plasma, is constantly and rapidly exchanged with fractions of the free hormone.

Due to the high level of protein binding, levothyroxine is not amenable to either hemodialysis or hemoperfusion.

The half-life is 7 days. With hyperthyroidism, this period is shortened to 3-4 days, and with hypothyroidism, it is extended to 9-10 days. The volume of distribution is 10-12 liters. The liver accumulates about 1/3 of the total amount of injected levothyroxine, quickly interacts with levothyroxine, which is in the blood serum. Thyroid hormones are metabolized primarily in the liver, kidneys, brain and muscles. Metabolites are excreted in urine and feces. The total metabolic clearance of levothyroxine is approximately 1.2 L of plasma / day.

Indications
Eutirox 25-200 mcg

Treatment of benign euthyroid goiter.
Prevention of relapse after surgical treatment of euthyroid goiter, depending on the level of the hormone in the postoperative period.
As replacement therapy for hypothyroidism.
Suppressive therapy for thyroid cancer.
Eutirox 25-100 mcg

As an adjunct drug for antithyroid therapy in hyperthyroidism.
Eutirox 100/150/200 mcg

As a diagnostic tool for a thyroid suppression test.

Contraindications
Hypersensitivity to the components of the drug.
Adrenal insufficiency, pituitary insufficiency, thyrotoxicosis, which have not been treated.
Acute myocardial infarction, acute myocarditis, acute pancarditis.
Combined therapy with levothyroxine and antithyroid drugs during pregnancy is prescribed (see section “Use during pregnancy or lactation”).