Description

Ezomeprazol (esomeprazole) Lyophilisate for Injections and Infusions 40 mg Vial №1

Ingredients:

Each vial contains 40 mg of esomeprazole.

Dosage:

The recommended dosage is 40 mg once daily via intravenous infusion over 10-30 minutes.

Indications:

Ezomeprazol is indicated for the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, and Zollinger-Ellison syndrome.

Contraindications:

Do not use Ezomeprazol if allergic to esomeprazole or substituted benzimidazoles.

Directions:

Administer as directed by a healthcare provider. Do not mix with other medications in the same infusion.

Scientific Evidence:

Esomeprazole, the active ingredient in Ezomeprazol, is a proton pump inhibitor that works by reducing the production of stomach acid. Studies have shown that esomeprazole is effective in healing and preventing relapse of erosive esophagitis and managing symptoms of GERD.

Pharmacological Effects:

Upon administration, esomeprazole is rapidly converted to its active form in the acidic environment of the parietal cells in the stomach. It irreversibly binds to the proton pump (H+/K+ ATPase) to inhibit the final step of acid production, leading to a decrease in gastric acid secretion.

Clinical Trials:

In a comparative study by Labenz et al., esomeprazole was found to provide more effective and faster relief of GERD symptoms compared to omeprazole. Additionally, a meta-analysis by Targownik et al. demonstrated the superior healing rates of esomeprazole in erosive esophagitis compared to other proton pump inhibitors.

Additional Information:

• Storage: Store Ezomeprazol lyophilisate at controlled room temperature between 20°C to 25°C.
• Adverse Reactions: Common side effects may include headache, nausea, and abdominal pain.
• Pregnancy and Lactation: Use with caution during pregnancy and breastfeeding, consult a healthcare provider.