$215.00
Manufacturer: Spain
Infections caused by Varicella Zoster (VZV) viruses – shingles shingles, including shingles with precise localization in immunocompetent adult patients; shingles in adult patients with weakened immune systems. Infections caused by Herpes Simplex viruses (HSV) – genital herpes treatment of the first manifestations and relapses of infectious genital herpes in immunocompetent adult patients; treatment of recurrent genital herpes in adult patients with weakened immune systems; inhibition of recurrent genital herpes in immunocompetent adult patients and in adult patients with weakened immunity.
Description
Famvir 250 mg Storage
active substance: famciclovir;
1 tablet of 125 mg contains 125 mg of famciclovir;
1 tablet of 250 mg contains 250 mg of famciclovir;
1 tablet of 500 mg contains 500 mg of famciclovir;
Famvir 250 mg Excipients:
hydroxypropylcellulose, lactose anhydrous, sodium starch glycolate, magnesium stearate, hypromellose, titanium dioxide (E 171), polyethylene glycol 4000, polyethylene glycol 6000 (500 mg tablets do not contain lactose anhydrous).
Famvir 250 mg Dosage form
Film-coated tablets.
Main physical and chemical properties: 125 mg and 250 mg tablets – white, round, biconvex film-coated tablets with beveled edges, embossed with “FV” on one side and “125” or “250” on the other side;
500 mg tablets are white, oval, biconvex, film-coated tablets with bevelled edges, embossed with FV 500 on one side and smooth on the other.
Pharmacotherapeutic group
Antiviral drugs of direct action. Nucleosides and nucleotides. Famciclovir. ATX code J05A B09.
Pharmacological properties
Pharmacodynamics.
Famciclovir is rapidly converted in vivo to penciclovir, which demonstrates in vitro antiviral activity against herpes simplex viruses (types 1 and 2), chickenpox virus, Epstein-Barr virus and cytomegalovirus.
The antiviral effect of orally administered famciclovir has been observed in various animal models. In virus-infected cells, penciclovir is rapidly and efficiently converted to triphosphate (this process is mediated indirectly by virus-induced thymidine kinase). This triphosphate is present in infected cells for more than 12 hours and inhibits viral DNA replication. Penciclovir triphosphate has a half-life of 10 hours in HSV-1 cells, 20 hours in HSV-2 cells, and 7 hours in VZV-infected cells grown in culture.
In uninfected cells exposed to penciclovir, the concentration of penciclovir triphosphate is barely detectable. Therefore, the likelihood of its toxic effect on mammalian cells is too low and uninfected cells are unlikely to be affected at therapeutic concentrations of penciclovir.
Indication
Varicella Zoster (VZV) Infections – Shingles
shingles, including shingles with ocular localization in immunocompetent adult patients;
shingles in adult patients with weakened immunity.
Infections caused by Herpes Simplex (HSV) viruses are genital herpes
treatment of the first manifestations and recurrences of infectious genital herpes in immunocompetent adult patients;
treatment of recurrence of genital herpes in adult patients with weakened immunity;
suppression of recurrent genital herpes in immunocompetent adult patients and in adult patients with weakened immunity.
Contraindication
Hypersensitivity to famciclovir or other components of the drug, as well as hypersensitivity to penciclovir.
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