Farington tablets №20

Description

FARINGTON COMPOSITION
active ingredients: 1 tablet contains chlorhexidine dihydrochloride 5 mg ascorbic acid 50 mg

Excipients:

FARINGTON DOSAGE FORM
Lozenges.

FARINGTON MAIN PHYSICAL AND CHEMICAL PROPERTIES:
tablets of a flat-cylindrical shape with beveled edges, pale orange. Intersperses are allowed on the surface of the tablets.

PHARMACOLOGICAL GROUP
Throat medications. Antiseptics. ATX code R02A A.

PHARMACOLOGICAL PROPERTIES

Pharmacological.

Farington is a combination drug consisting of two components. Chlorhexidine has an antibacterial effect by nonspecific binding to phospholipids of the bacterial cell membrane, where chlorhexidine inhibits the activity of dehydrogenase and ATPase and violates the membrane permeability for potassium, nucleotides and amino acids.

Chlorhexidine acts as a bacteriostatic drug at low concentrations (less than 20 mg / L) and as a bactericidal drug at high concentrations. Its action is directed mainly against gram-positive microorganisms and Candida albicans and, to a lesser extent, against gram-negative microorganisms. Chlorhexidine is especially effective against Streptococcus mutans, Streptococcus salvarius, Escherichia coli, Selenomonas, anaerobic bacteria and Candida albicans. Slightly less effective against Streptococcus sanquis, Proteus, Pseudomonas, Klebsiella and Veillonella species.

Ascorbic acid reduces inflammation and swelling of the mucous membranes in the mouth and nasopharynx, enhances the immune response and acts as a co-factor in collagen synthesis and tissue regeneration.

Pharmacokinetics.

Chlorhexidine is practically not absorbed through the mucous membrane and skin. During sucking, chlorhexidine is gradually released from the tablets into saliva and binds to the mucous membrane of the mouth and tongue, after which it again enters the saliva, where its antibacterial effect is manifested. Chlorhexidine can be swallowed in saliva, but absorption from the gastrointestinal tract is very low. Chlorhexidine is slightly metabolized in the liver and excreted in the bile through the intestines. Usually 90% of the chlorhexidine consumed is excreted unchanged in the feces.

The concentration of chlorhexidine in body fluids is measured by high performance liquid chromatography with a method sensitivity of up to 1 mg / L.

Ascorbic acid is well absorbed from the gastrointestinal tract. The degree of its binding to blood plasma proteins is approximately 25%. Ascorbic acid is metabolized to dihydroascorbic and oxalic acids, excreted in the urine.

INDICATIONS
Local treatment of symptoms of inflammation of the mucous membrane of the throat and larynx.

CONTRAINDICATIONS
Hypersensitivity to chlorhexidine or to any other component of the drug.

INTERACTION WITH OTHER DRUGS AND OTHER INTERACTIONS
There are no reports of cases of interaction with other drugs.

FEATURES OF APPLICATION
The use of the drug may temporarily slightly alter the taste sensation, but within 4 hours after taking the drug, taste perception is fully restored. It is recommended to take the drug after meals.

Pharyngton should not be taken for more than 14 days, on average it should be used for 5-7 days.

Due to the presence of sugar in the composition of the drug, it should be used carefully for the treatment of patients with diabetes mellitus and with a tendency to caries.

Long-term use of Farington can cause a slight temporary change in the color of the teeth and tongue, but these phenomena disappear after the drug is discontinued or a doctor’s advice may be required to eliminate them.

Sometimes patients with diseases of the gastrointestinal tract and / or liver may complain of nausea, vomiting and belching. If these symptoms appear, the drug should be discontinued.