$41.00
Manufacturer: Ukraine
Treatment of diabetic patients who need insulin to maintain normal glucose homeostasis.
Description
Farmasulin H Composition
active substance: human biosynthetic insulin (DNA recombinant);
1 ml of human biosynthetic insulin (DNA recombinant) 100 IU;
excipients: metacresol; glycerin acid diluted hydrochloric or sodium hydroxide solution; water for injections.
Farmasulin H Dosage form
Injection.
Basic physical and chemical properties: clear, colorless liquid.
Farmasulin H Pharmacotherapeutic group
Antidiabetic drugs. Insulin preparations. Insulins and short-acting analogues. ATX code А10А В01.
Pharmacodynamics
Farmasulin H is a short-acting insulin preparation.
The main action of insulin is to regulate glucose metabolism. In addition, insulin affects several anabolic and anti-catabolic processes in various tissues. In muscle tissues, these effects include an increase in the synthesis of glycogen, fatty acids, glycerol and protein, as well as an increase in the absorption of amino acids and with a simultaneous suppression of the processes of glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism and the release of amino acids.
The figure below in the form of a bold line shows a typical profile of insulin activity (glucose utilization curve) after drug administration. Possible variability in the duration of insulin activity and / or its intensity in different patients is depicted as a shaded area in the graph. Individual variability depends on factors such as dose volume, temperature at the injection site, and the patient’s level of physical activity.
Pharmacokinetics
The drug Farmasulin H is a human insulin that is produced using technologies using recombinant DNA.
The pharmacokinetics of insulin do not reflect the metabolic activity of the hormone. Therefore, when considering the question of insulin activity, it would be more appropriate to study the glucose utilization curves (given above).
During the toxicological studies, no serious harmful effects associated with the use of the drug were identified.
Indications
Treatment of diabetic patients requiring insulin administration to maintain normal glucose homeostasis.
Contraindications
Hypoglycemia. Hypersensitivity to the active substance and to any excipients of the drug, with the exception of cases of the use of desensitizing therapy.
Incompatibility.
Do not mix Farmasulin H with insulins from other manufacturers and with insulins of animal origin.
Interaction with other medicinal products and other types of interactions
Some drugs affect glucose metabolism, so you should consult your doctor about taking any other drugs with human insulin. The physician should take into account possible interactions if the patient is taking any medications.
The need for insulin may increase with the use of drugs with hyperglycemic activity, such as glucocorticoids, thyroid hormones and growth hormone, danazol, β2-sympathomimetics (for example, ritodrin, salbutamol, terbutaline), thiazides.
The need for insulin may decrease with the use of drugs with hypoglycemic activity, such as oral hypoglycemic drugs, salicylates (for example, acetylsalicylic acid), some antidepressants (MAO inhibitors), some ACE inhibitors (captopril, enalapril), angiotensin II receptor blockers, non-angiotensin II receptor blockers β-blockers or alcohol.
Somatostatin analogs (octreotide, lanreotide) can both increase and decrease the need for insulin.
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