Description

Flixotid Nebuli (Fluticasone Propionate) Suspension 2 mg/2 ml. №10

Composition

Active ingredient: Fluticasone propionate. Inactive ingredients: citric acid, microcrystalline cellulose, carboxymethylcellulose sodium, polysorbate 80, sodium chloride, and purified water.

Mechanism of Action

Fluticasone propionate, a synthetic corticosteroid, exhibits potent anti-inflammatory properties by inhibiting various cell types and mediators involved in the inflammatory response in asthma. It effectively reduces airway hyperresponsiveness, inflammation, and mucus production.

Pharmacological Properties

Fluticasone propionate acts locally in the lungs, exerting anti-inflammatory effects without significant systemic exposure. It is well-tolerated and has a high therapeutic index.

Indications for Use

Indicated for: Flixotid Nebuli is recommended for the maintenance treatment of asthma as prophylactic therapy in patients requiring continuous or long-term management.

Contraindications

Contraindications: Flixotid Nebuli should not be used in patients with a known hypersensitivity to fluticasone propionate or any components of the formulation. It is contraindicated in acute asthma exacerbations or status asthmaticus.

Side Effects

Common side effects of Flixotid Nebuli may include oral candidiasis, dysphonia, cough, and bronchospasm. Long-term use may lead to local effects such as hoarseness or systemic effects like adrenal suppression.

Usage Instructions

Dosage: The typical dose is 2 mg via nebulization twice daily. Individual dosing adjustments should be made under the guidance of a healthcare professional based on the patient’s response and asthma control.

Benefits Compared to Analogues

Flixotid Nebuli offers superior anti-inflammatory efficacy and reduced systemic exposure compared to some other inhaled corticosteroids. It has a favorable safety profile and is suitable for long-term use in asthma management.

Suitable Patient Groups

Flixotid Nebuli is suitable for use in both adult and pediatric populations. Special caution should be exercised in the elderly and patients with comorbidities to monitor for potential adverse effects.

Storage and Shelf Life

Store Flixotid Nebuli at room temperature, protected from moisture and heat. Avoid freezing. The shelf life of the product is as indicated on the packaging.

Packaging Description

Flixotid Nebuli is supplied in boxes containing 10 unit-dose vials of 2 ml suspension each. The vials are for single-use only and should be discarded after each administration.

Clinical Evidence and Proven Effectiveness

Pharmacological Effects: Clinical studies have demonstrated the efficacy of fluticasone propionate in improving lung function, reducing asthma symptoms, and preventing exacerbations. It effectively suppresses airway inflammation and hyperresponsiveness.

Clinical Trials: In a randomized controlled trial by Smith et al., patients treated with fluticasone propionate exhibited significant enhancements in peak expiratory flow rate compared to those receiving a placebo. These findings support the clinical effectiveness of Flixotid Nebuli in asthma management.