Description
Fluconazol (Fluconazole) Forte Capsules 200 mg. №7
Ingredients:
Each capsule contains 200 mg of fluconazole.
Mechanism of Action:
Fluconazole, a triazole antifungal agent, inhibits the fungal cytochrome P450 enzyme 14α-demethylase. This action disrupts the synthesis of ergosterol, a vital component of fungal cell membranes, leading to membrane destabilization and fungal cell death.
Pharmacological Properties:
Fluconazole exhibits fungistatic activity against a wide range of pathogenic fungi, including Candida spp. and Cryptococcus neoformans. It is well-absorbed orally and reaches therapeutic concentrations in various body tissues, including the central nervous system.
Indications for Use:
- Treatment of candidiasis infections, including vaginal candidiasis
- Management of cryptococcal meningitis
- Prophylaxis of fungal infections in immunocompromised patients
Contraindications:
Avoid Fluconazol capsules if you have a known hypersensitivity to fluconazole or other azole antifungals. Use with caution in patients with hepatic impairment or history of QT prolongation.
Side Effects:
Common side effects may include nausea, headache, abdominal pain, and rash. Rare but serious adverse reactions may include hepatotoxicity, anaphylaxis, and Stevens-Johnson syndrome. Monitor for signs of drug interactions and adverse effects during therapy.
Usage Instructions:
Take one capsule orally once daily with a full glass of water. Do not crush or chew the capsule. Dosage adjustments may be necessary in patients with renal dysfunction. Follow the prescribed treatment duration for optimal therapeutic outcomes.
Benefits Compared to Analogues:
Fluconazol forte capsules offer the advantage of convenient once-daily dosing, broad-spectrum antifungal activity, and favorable tissue penetration compared to other azole antifungals. The formulation provides consistent plasma concentrations, reducing the risk of dosing errors.
Suitable Patient Groups:
Fluconazol forte capsules are suitable for use in pediatric and adult populations. Dosage adjustments may be required in elderly patients and those with renal impairment. Consult a healthcare professional for individualized dosing recommendations.
Storage Conditions and Shelf Life:
Store Fluconazol forte capsules at controlled room temperature away from moisture and light. Check the expiration date on the packaging and do not use expired medication. Keep out of reach of children.
Packaging Description:
Each package contains 7 capsules of Fluconazol forte 200 mg. The capsules are sealed in blister packs to maintain product integrity and protect from environmental factors.
Clinical Evidence and Proven Effectiveness:
Fluconazole has demonstrated efficacy in numerous clinical trials for the treatment of various fungal infections. Clinical studies have shown that fluconazole is well-tolerated and effective in both localized and systemic fungal diseases. Consult published literature for specific study findings and recommendations.
