Description

Fluconazol (Fluconazole) Solution for Infusions 2 mg/ml. 50 ml

Ingredients

Active ingredient: Fluconazole. Inactive ingredients may include sodium chloride, hydrochloric acid, and water for injections.

Dosage

Recommended dosage: The usual dose is 400 mg on the first day, followed by 200-400 mg once daily. Dosage adjustments may be needed based on the patient’s condition.

Indications

Indicated for: Treatment of various fungal infections, including candidiasis, cryptococcal meningitis, and others caused by susceptible strains of fungi.

Contraindications

Contraindicated in: Patients with known hypersensitivity to fluconazole or other azole antifungals. Use with caution in patients with liver or kidney dysfunction.

Directions

Administration: Administer by slow intravenous infusion over 30-60 minutes. Follow the healthcare provider’s instructions carefully.

Scientific Evidence

Pharmacological Effects: Fluconazole inhibits the synthesis of ergosterol, a key component of fungal cell membranes, leading to cell membrane disruption and fungal cell death. It is well-absorbed and reaches therapeutic levels in various body tissues.

Clinical Trials: Clinical studies have demonstrated the efficacy of fluconazole in treating various fungal infections, showing high cure rates and good tolerability profiles. Research by Pappas et al. (2016) highlighted the effectiveness of fluconazole in the treatment of invasive candidiasis.

Additional Information

Fluconazol solution for infusions is a valuable option in the management of serious fungal infections, offering convenience and reliable efficacy. It is important to monitor liver function tests during prolonged therapy to prevent potential hepatotoxicity.

Consult with a healthcare professional for personalized dosing recommendations and to discuss any potential drug interactions. Store the solution at controlled room temperature and protect from light.