Funit capsules 100 mg. №4

Description

FUNIT №4 COMPOSITION

active substance: itraconazole; 1 capsule contains 100 mg of itraconazole. Excipients: hypromellose, polyethylene glycol 6000; neutral micropellets: spherical sugar, corn starch gelatin capsule: azorubin (E 122), patented blue V (E 131), titanium dioxide (E 171), caramel (E 150), gelatin.

FUNIT №4 DOSAGE FORM

Capsules.

FUNIT №4 MAIN PHYSICAL AND CHEMICAL PROPERTIES:

hard gelatin capsules with a pink lid and a brown body, containing spherical micropellets from white to almost white.

PHARMACOLOGICAL GROUP

Antifungal agents for systemic use. Triazole derivatives ATC code J02A C02.

PHARMACOLOGICAL PROPERTIES

Pharmacological. Itraconazole is a triazole derivative that has a wide spectrum of action. Itraconazole inhibits the synthesis of ergosterol in fungal cells. Ergosterol is an important component of the fungal cell membrane, inhibition of its synthesis provides an antifungal effect. With respect to itraconazole, limit values ​​are set only for Candida spp. For superficial mycotic infections (CLSI M27-A2, limit values ​​not established by EUCAST methodology). The CLSI limit values ​​are as follows: sensitive ≤ 0.125; sensitive dose-dependent 0.25-0.5 and resistant ≥ 1 μg / ml. Limit values ​​have not been established for filamentous fungi.

INDICATIONS

Vulvovaginal candidiasis pityriasis versicolor; dermatomycosis caused by pathogens sensitive to itraconazole (Trichophyton spp., Microsporum spp., Epidermophyton floccosum), for example, dermatophytosis of the feet, inguinal dermatomycosis, dermatophytosis of the trunk, dermatophytosis of the hands; oropharyngeal candidiasis onychomycosis caused by dermatophytes and / or yeast; histoplasmosis; systemic mycoses (in cases where first-line antifungal therapy cannot be applied or if treatment with other antifungal drugs is ineffective, which may be due to the existing pathology, pathogen insensitivity or drug toxicity) aspergillosis and candidiasis cryptococcosis (including cryptococcal meningitis): treatment of immunocompromised patients with cryptococcosis and all patients with cryptococcosis of the central nervous system; maintenance therapy in patients with AIDS in order to prevent recurrence of the existing fungal infection. Funit can also be prescribed to prevent fungal infections in patients with prolonged neutropenia in cases where standard therapy is insufficient.

CONTRAINDICATIONS

Funit capsules are contraindicated in patients with known hypersensitivity to the active substance or to any of the excipients.