Description
Glibenclamide Tablets 5 mg. №100
Ingredients
Each tablet contains 5 mg of Glibenclamide.
Mechanism of Action
Glibenclamide acts by binding to specific receptors on pancreatic beta cells, leading to the release of insulin. This mechanism helps lower blood sugar levels in diabetic patients.
Pharmacological Properties
Glibenclamide acts by closing ATP-sensitive potassium channels in the pancreatic beta cells, leading to depolarization and subsequent calcium influx, which triggers insulin release. This process helps regulate blood glucose levels in diabetic patients.
Indications for Use
Glibenclamide is indicated for the treatment of type 2 diabetes mellitus. It helps lower blood sugar levels by stimulating the release of insulin from the pancreas.
Contraindications
Do not use Glibenclamide if you have type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, or a history of an allergic reaction to sulfonylureas.
Side Effects
Common side effects of Glibenclamide may include hypoglycemia, weight gain, gastrointestinal disturbances, and allergic reactions. It is important to consult a healthcare provider for a complete list of side effects.
Usage Instructions
The usual dose of Glibenclamide is 2.5 to 15 mg daily, taken with breakfast or the first main meal. It is important to take Glibenclamide exactly as prescribed by your healthcare provider. Follow all directions on your prescription label.
Benefits Compared to Analogues
Glibenclamide has been shown to be comparable in effectiveness to other sulfonylureas in controlling blood glucose levels. Its mechanism of action and pharmacological properties make it a valuable option for managing type 2 diabetes mellitus.
Suitable Patient Groups
Glibenclamide is suitable for adult patients with type 2 diabetes mellitus. It may not be recommended for use in children, pregnant women, or elderly patients with specific health conditions. Consult a healthcare provider for personalized recommendations.
Storage and Shelf Life
Store Glibenclamide tablets in a cool, dry place away from direct sunlight. Keep the medication out of reach of children. Check the expiration date on the packaging and do not use the tablets after the specified shelf life.
Packaging Description
Glibenclamide tablets are typically packaged in a container with 100 tablets per pack. The packaging should include important information such as the name of the product, dosage strength, batch number, and expiration date.
Clinical Evidence and Proven Effectiveness
Glibenclamide, a sulfonylurea, has been extensively studied for its efficacy in managing type 2 diabetes. Research published in the Journal of Clinical Pharmacy and Therapeutics demonstrated that Glibenclamide effectively reduces HbA1c levels, indicating improved long-term blood sugar control.
