Description

Glibenclamid Tablets 5 mg. №100

Ingredients

Each tablet contains 5 mg of Glibenclamide.

Dosage

The usual dose is 2.5 to 15 mg daily, taken with breakfast or the first main meal.

Indications

Glibenclamide is indicated for the treatment of type 2 diabetes mellitus. It helps lower blood sugar levels by stimulating the release of insulin from the pancreas.

Contraindications

Do not use Glibenclamide if you have type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, or a history of an allergic reaction to sulfonylureas.

Directions

Take Glibenclamide exactly as prescribed by your healthcare provider. Follow all directions on your prescription label.

Scientific Evidence

Glibenclamide, a sulfonylurea, has been extensively studied for its efficacy in managing type 2 diabetes. Research published in the Journal of Clinical Pharmacy and Therapeutics demonstrated that Glibenclamide effectively reduces HbA1c levels, indicating improved long-term blood sugar control.

Additional Information

Glibenclamide works by binding to specific receptors on pancreatic beta cells, leading to the release of insulin. This mechanism helps lower blood sugar levels in diabetic patients. Clinical trials have shown that Glibenclamide is comparable in effectiveness to other sulfonylureas in controlling blood glucose levels.

Pharmacological Effects: Glibenclamide acts by closing ATP-sensitive potassium channels in the pancreatic beta cells, leading to depolarization and subsequent calcium influx, which triggers insulin release. This process helps regulate blood glucose levels in diabetic patients.

Clinical Trials: A study published in Diabetes Care compared the effectiveness of Glibenclamide with other oral antidiabetic agents and found that Glibenclamide was equally effective in lowering HbA1c levels and improving glycemic control.